SETD1A, SET domain containing 1A, histone lysine methyltransferase

SETD1A, SET domain containing 1A, histone lysine methyltransferase

• The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]

• Gene Synonyms (histone-lysine N-methyltransferase SETD1A, SET domain containing 1A, SET domain-containing protein 1A, hSET1A, lysine N-methyltransferase 2F, set1/Ash2 histone methyltransferase complex subunit SET1, EPEDD, KMT2F, Set1, Set1A,)
• NCBI Gene ID: 9739
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15047
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SET domain containing 1A, histone lysine methyltransferase interacts with:

• AHNAK nucleoprotein
  anaphase promoting complex subunit 7
  biorientation of chromosomes in cell division 1 like 1
  CCCTC-binding factor
  chromobox 3
  chromodomain helicase DNA binding protein 8
  CTD small phosphatase 2
  CXXC finger 1 (PHD domain)
  CXXC finger protein 1
  DDB1 and CUL4 associated factor 4
  dpy-30 histone methyltransferase complex regulatory subunit
  erythrocyte membrane protein band 4.1 like 3
  erythrocyte membrane protein band 4.1 like 5
  H3 clustered histone 14
  histone deacetylase 6
  host cell factor C2
  INO80 complex subunit E
  LanC like 1
  nucleoporin 50
  pescadillo ribosomal biogenesis factor 1
  PHD finger protein 5A
  pleckstrin homology domain containing A4
  PNN interacting serine and arginine rich protein
  pre-mRNA processing factor 19
  RAD18 E3 ubiquitin protein ligase
  Rho GTPase activating protein 10
  round spermatid basic protein 1
  RuvB like AAA ATPase 2
  SET domain containing 1B, histone lysine methyltransferase
  SMC hinge domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  TBC1 domain family member 10B
  TNFAIP3 interacting protein 2
  transcription elongation regulator 1
  tripartite motif containing 28
  UV stimulated scaffold protein A
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 82

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.