SETDB1, SET domain bifurcated histone lysine methyltransferase 1

SETDB1, SET domain bifurcated histone lysine methyltransferase 1

• This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

• Gene Synonyms (histone-lysine N-methyltransferase SETDB1, ERG-associated protein with a SET domain, ESET, SET domain bifurcated 1, histone H3-K9 methyltransferase 4, histone-lysine N-methyltransferase, H3lysine-9 specific 4, lysine N-methyltransferase 1E, tudor domain containing 21, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21,)
• NCBI Gene ID: 9869
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15047
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SET domain bifurcated histone lysine methyltransferase 1 interacts with:

• activating transcription factor 7 interacting protein
  activating transcription factor 7 interacting protein 2
  acyl-CoA thioesterase 9
  biogenesis of ribosomes BRX1
  BTB domain containing 2
  calsyntenin 1
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  chromatin assembly factor 1 subunit A
  chromobox 5
  chromobox 8
  chromosome 11 open reading frame 1
  coiled-coil domain containing 106
  coiled-coil domain containing 85C
  cysteine rich with EGF like domains 1
  DNA polymerase alpha 2, accessory subunit
  ECSIT signaling integrator
  establishment of sister chromatid cohesion N-acetyltransferase 1
  establishment of sister chromatid cohesion N-acetyltransferase 2
  exocyst complex component 4
  exocyst complex component 5
  family with sequence similarity 118 member B
  Fas associated factor family member 2
  F-box protein 30
  FLYWCH-type zinc finger 1
  GIPC PDZ domain containing family member 2
  H3 clustered histone 15
  H4 histone 16
  heat shock transcription factor 2 binding protein
  HECT domain E3 ubiquitin protein ligase 1
  ligand dependent nuclear receptor interacting factor 1
  LUC7 like 2, pre-mRNA splicing factor
  lysine demethylase 1A
  mitochondrial calcium uniporter dominant negative subunit beta
  mitochondrial ribosomal protein L44
  mitogen-activated protein kinase kinase kinase kinase 5
  mitotic spindle organizing protein 2B
  MOB family member 4, phocein
  nipsnap homolog 3A
  nuclear RNA export factor 1
  olfactomedin like 3
  ORAI calcium release-activated calcium modulator 2
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD finger protein 10
  pleckstrin homology domain containing A4
  protein inhibitor of activated STAT 4
  protocadherin alpha 4
  queuine tRNA-ribosyltransferase catalytic subunit 1
  replication timing regulatory factor 1
  ring finger protein 10
  seryl-aminoacyl-tRNA synthetase
  SIN3 transcription regulator family member A
  SIN3 transcription regulator family member B
  Smad nuclear interacting protein 1
  solute carrier family 38 member 3
  SUFU negative regulator of hedgehog signaling
  SUZ12 polycomb repressive complex 2 subunit
  TAR DNA binding protein
  THAP domain containing 8
  thioredoxin domain containing 9
  toll interacting protein
  transcription elongation regulator 1
  transducer of ERBB2, 1
  tribbles pseudokinase 3
  tripartite motif containing 16
  tripartite motif containing 28
  WASH complex subunit 3
  ZFP64 zinc finger protein
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger protein 274

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.