RBM5, RNA binding motif protein 5

RBM5, RNA binding motif protein 5

• This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

• Gene Synonyms (RNA-binding protein 5, putative tumor suppressor LUCA15, renal carcinoma antigen NY-REN-9, G15, H37, LUCA-15, LUCA15, RMB5,)
• NCBI Gene ID: 10181
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52756
  UNIPROT ID#>>A0A024R2U6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA binding motif protein 5 interacts with:

• centrosomal protein 43
  COP9 signalosome subunit 5
  DEAD-box helicase 17
  F-box and WD repeat domain containing 11
  jun B proto-oncogene
  kinesin family member 19
  kinesin family member 9
  kinesin family member C1
  ligand dependent nuclear receptor interacting factor 1
  LSM8 homolog, U6 small nuclear RNA associated
  malonyl-CoA decarboxylase
  membrane magnesium transporter 1
  MIS12 kinetochore complex component
  nuclear RNA export factor 1
  nudE neurodevelopment protein 1 like 1
  par-3 family cell polarity regulator beta
  PHD finger protein 19
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  RAD18 E3 ubiquitin protein ligase
  RNA binding motif protein 14
  RNA binding motif protein 17
  small nuclear ribonucleoprotein U5 subunit 200
  SUZ12 polycomb repressive complex 2 subunit
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  WD repeat domain 77
  WW domain binding protein 11
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.