PRPF8, pre-mRNA processing factor 8

PRPF8, pre-mRNA processing factor 8

• Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HPRP8, PRP8, PRPC8, RP13, SNRNP220, pre-mRNA-processing-splicing factor 8, 220 kDa U5 snRNP-specific protein, PRP8 homolog, PRP8 pre-mRNA processing factor 8 homolog, U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p, apoptosis-regulated protein 1, apoptosis-regulated protein 2, p220, precursor mRNA processing protein, splicing factor Prp8,)
• NCBI Gene ID: 10594
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6P2Q9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pre-mRNA processing factor 8 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  AAR2 splicing factor
  activating signal cointegrator 1 complex subunit 1
  agrin
  AHNAK nucleoprotein
  ankyrin repeat and SOCS box containing 15
  arginine and serine rich coiled-coil 1
  biogenesis of ribosomes BRX1
  bolA family member 2
  breast carcinoma amplified sequence 2
  bromodomain containing 7
  cap methyltransferase 1
  cell division cycle 40
  cell division cycle 5-like (S. pombe)
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 8
  chromosome 1 open reading frame 131
  chromosome 9 open reading frame 78
  coiled-coil domain containing 12
  coiled-coil domain containing 8
  crooked neck pre-mRNA splicing factor 1
  CWF19 like cell cycle control factor 1
  cyclin-dependent kinase 1
  cytoskeleton associated protein 4
  decapping enzyme, scavenger
  dermcidin
  DExH-box helicase 30
  DNA polymerase delta interacting protein 2
  DnaJ heat shock protein family (Hsp40) member B4
  DnaJ heat shock protein family (Hsp40) member C17
  DnaJ heat shock protein family (Hsp40) member C17
  dual specificity phosphatase 16
  dual specificity phosphatase 26
  E2F associated phosphoprotein
  EBNA1 binding protein 2
  ecdysoneless cell cycle regulator
  endoplasmic reticulum protein 44
  epiplakin 1
  eukaryotic translation initiation factor 3 subunit K
  F-box protein 22
  F-box protein 3
  F-box protein 6
  F-box protein 7
  filaggrin family member 2
  forkhead box Q1
  G protein-coupled receptor 156
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 5
  glutamate rich WD repeat containing 1
  G-patch domain and KOW motifs
  GRB10 interacting GYF protein 2
  HEXIM P-TEFb complex subunit 1
  immunoglobulin superfamily member 8
  ISY1 splicing factor homolog
  ISY1-RAB43 readthrough
  junction plakoglobin
  kelch domain containing 10
  KIAA1143
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing 15
  leucine rich repeat containing 59
  leucine rich repeat containing G protein-coupled receptor 4
  leucyl-tRNA synthetase 1
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM8 homolog, U6 small nuclear RNA associated
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  methylphosphate capping enzyme
  methyltransferase like 14
  mex-3 RNA binding family member C
  MINDY lysine 48 deubiquitinase 4
  mitochondrial ribosomal protein S27
  neurochondrin
  neutrophil cytosolic factor 1
  NHL repeat containing 2
  NOP2/Sun RNA methyltransferase 2
  nudix hydrolase 21
  obscurin like cytoskeletal adaptor 1
  p53 and DNA damage regulated 1
  Parkinsonism associated deglycase
  PAX3 and PAX7 binding protein 1
  peptidylprolyl isomerase domain and WD repeat containing 1
  peptidylprolyl isomerase like 1
  peptidylprolyl isomerase like 2
  peptidylprolyl isomerase like 3
  peroxiredoxin 3
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD finger protein 6
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  phosphoglycerate dehydrogenase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(U) binding splicing factor 60
  polyglutamine binding protein 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 31
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  pre-mRNA processing factor 8
  prohibitin 2
  prostaglandin E synthase 3
  PTEN induced kinase 1
  RALY heterogeneous nuclear ribonucleoprotein
  regulator of chromosome condensation 2
  replication termination factor 2
  ribosomal protein L13a
  ribosomal protein L36
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 20
  ring finger protein 31
  RIO kinase 1
  RNA binding motif protein 22
  RNA binding protein with serine rich domain 1
  RNA polymerase II associated protein 3
  RuvB like AAA ATPase 2
  serine peptidase inhibitor Kazal type 5
  serine/arginine repetitive matrix 2
  SERPINE1 mRNA binding protein 1
  sirtuin 6
  sirtuin 7
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  SNW domain containing 1
  SNW domain containing 1
  solute carrier family 4 member 1 adaptor protein
  solute carrier family 7 member 6 opposite strand
  spindle apparatus coiled-coil protein 1
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  SPT16 homolog, facilitates chromatin remodeling subunit
  squamous cell carcinoma antigen recognized by T cells 1
  staphylococcal nuclease and tudor domain containing 1
  stress induced phosphoprotein 1
  SUZ12 polycomb repressive complex 2 subunit
  tetratricopeptide repeat domain 27
  thioredoxin domain containing 5
  thioredoxin like 4A
  TNFAIP3 interacting protein 2
  transcription elongation regulator 1
  translocase of inner mitochondrial membrane 50
  transmembrane protein 33
  tripartite motif containing 55
  TSR1 ribosome maturation factor
  tubulin alpha 1c
  tubulin beta class I
  tuftelin interacting protein 11
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 39
  vir like m6A methyltransferase associated
  von Willebrand factor A domain containing 8
  WD repeat domain 83
  WD repeat domain 92
  WW domain binding protein 11
  WW domain binding protein 11
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  XPA binding protein 2
  X-prolyl aminopeptidase 3
  zinc finger and BTB domain containing 46
  zinc finger and BTB domain containing 7B
  zinc finger CCCH-type and G-patch domain containing
  zinc finger CCCH-type containing 18
  zinc finger containing ubiquitin peptidase 1
  zinc finger MYND-type containing 11
  zinc finger protein 746
  zinc finger protein 830

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.