SAMHD1, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

SAMHD1, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

• This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]

• Gene Synonyms (deoxynucleoside triphosphate triphosphohydrolase SAMHD1, SAM domain and HD domain 1, SAM domain and HD domain-containing protein 1, dNTPase, dendritic cell-derived IFNG-induced protein, monocyte protein 5, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, hSAMHD1,)
• NCBI Gene ID: 25939
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y3Z3
  UNIPROT ID#>>Q59H15
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 interacts with:

• ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  autophagy and beclin 1 regulator 1
  bromodomain containing 7
  cyclin L2
  decapping enzyme, scavenger
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 13 member B
  F-box protein 25
  G-patch domain containing 4
  heat shock transcription factor 5
  KAT8 regulatory NSL complex subunit 3
  ligand dependent nuclear receptor corepressor
  limb development membrane protein 1 like
  N(alpha)-acetyltransferase 10, NatA catalytic subunit
  pleckstrin homology domain containing A4
  PR/SET domain 16
  Rac GTPase activating protein 1
  receptor interacting serine/threonine kinase 4
  retinol dehydrogenase 13
  ring finger protein 123
  round spermatid basic protein 1 like
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  serine/threonine/tyrosine interacting like 1
  spindle and centriole associated protein 1
  suppressor of glucose, autophagy associated 1
  testis expressed 101
  TIR domain containing adaptor protein
  TNFAIP3 interacting protein 2
  tRNA methyltransferase 1
  unc-93 homolog B1, TLR signaling regulator
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  zinc finger matrin-type 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.