GJA8, gap junction protein alpha 8

GJA8, gap junction protein alpha 8

• This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]

• Gene Synonyms (gap junction alpha-8 protein, cell surface glycoprotein, connexin 50, gap junction alpha 8, gap junction membrane channel protein alpha-8, gap junction protein alpha 8 50kDa, lens fiber protein MP70, lens intrinsic membrane protein MP70, CAE, CAE1, CTRCT1, CX50, CZP1, MP70,)
• NCBI Gene ID: 2703
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X5D7G1
  UNIPROT ID#>>P48165
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gap junction protein alpha 8 interacts with:

• ADP ribosylation factor like GTPase 6 interacting protein 6
  anterior gradient 2, protein disulphide isomerase family member
  apolipoprotein L3
  C2CD2 like
  C-C motif chemokine ligand 4
  chromosome 3 open reading frame 52
  claudin 19
  CLN6 transmembrane ER protein
  coiled-coil domain containing 167
  core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
  cortexin 3
  C-type lectin domain family 1 member A
  C-X-C motif chemokine ligand 16
  cytochrome b-245 chaperone 1
  cytochrome c oxidase assembly factor COX20
  cytochrome P450 family 4 subfamily F member 2
  cytosolic iron-sulfur assembly component 2A
  defensin beta 121
  dolichol kinase
  endoplasmic reticulum metallopeptidase 1
  FXYD domain containing ion transport regulator 6
  G protein-coupled receptor 108
  G protein-coupled receptor 151
  G protein-coupled receptor 61
  gap junction protein beta 2
  GTPase, IMAP family member 1
  GTPase, IMAP family member 5
  guanylate cyclase activator 2A
  insulin induced gene 2
  insulin like growth factor binding protein 5
  integrin subunit alpha M
  killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
  leptin receptor overlapping transcript like 1
  LHFPL tetraspan subfamily member 5
  linker for activation of T cells
  lysosomal protein transmembrane 4 beta
  major facilitator superfamily domain containing 11
  major facilitator superfamily domain containing 6
  major intrinsic protein of lens fiber
  mal, T cell differentiation protein
  mal, T cell differentiation protein like
  membrane associated ring-CH-type finger 2
  membrane spanning 4-domains A13
  microsomal glutathione S-transferase 2
  ORMDL sphingolipid biosynthesis regulator 2
  otopetrin 2
  pancreatic lipase related protein 1
  peripheral myelin protein 22
  phospholamban
  post-GPI attachment to proteins 2
  PRA1 domain family member 2
  prokineticin receptor 2
  protein tyrosine phosphatase receptor type N
  purinergic receptor P2Y13
  pyroglutamylated RFamide peptide receptor
  receptor accessory protein 6
  relaxin family peptide/INSL5 receptor 4
  ring finger protein 152
  RUS family member 1
  scavenger receptor class F member 1
  SEC22 homolog B, vesicle trafficking protein
  SEC22 homolog C, vesicle trafficking protein
  Sec23 homolog A, COPII coat complex component
  single-pass membrane protein with coiled-coil domains 4
  small integral membrane protein 1 (Vel blood group)
  solute carrier family 13 member 2
  solute carrier family 13 member 5
  solute carrier family 16 member 12
  solute carrier family 16 member 13
  solute carrier family 16 member 3
  solute carrier family 30 member 3
  solute carrier family 35 member A4
  solute carrier family 35 member F1
  solute carrier family 35 member F6
  solute carrier family 38 member 4
  solute carrier family 38 member 7
  solute carrier family 39 member 2
  solute carrier family 39 member 7
  solute carrier family 39 member 9
  solute carrier family 52 member 1
  solute carrier family 66 member 1
  solute carrier family 66 member 2
  solute carrier family 8 member A3
  sphingosine-1-phosphate receptor 5
  surfactant protein C
  syntaxin 1B
  syntaxin 8
  tetraspanin 33
  thrombospondin type 1 domain containing 7B
  tight junction protein 1
  transmembrane BAX inhibitor motif containing 6
  transmembrane protein 100
  transmembrane protein 107
  transmembrane protein 121
  transmembrane protein 128
  transmembrane protein 147
  transmembrane protein 182
  transmembrane protein 239
  transmembrane protein 242
  transmembrane protein 243
  transmembrane protein 42
  transmembrane protein 45A
  transmembrane protein 60
  transmembrane protein 65
  transmembrane protein 72
  transmembrane protein 86B
  twisted gastrulation BMP signaling modulator 1
  UBX domain protein 8
  unc-93 homolog A
  uroplakin 1B
  vesicle associated membrane protein 5
  Yip1 domain family member 6
  Yip1 interacting factor homolog A, membrane trafficking protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.