TUBGCP4, tubulin gamma complex associated protein 4

TUBGCP4, tubulin gamma complex associated protein 4

• This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

• Gene Synonyms (gamma-tubulin complex component 4, gamma tubulin ring complex protein (76p gene), gamma-ring complex protein 76 kDa, 76P, GCP-4, GCP4, Grip76, MCCRP3,)
• NCBI Gene ID: 27229
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UGJ1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tubulin gamma complex associated protein 4 interacts with:

• ADAMTS like 4
  catenin beta like 1
  chibby family member 2
  chromodomain helicase DNA binding protein 8
  ciliogenesis and planar polarity effector 1
  EF-hand domain containing 2
  elongation factor like GTPase 1
  Fas binding factor 1
  ferredoxin-fold anticodon binding domain containing 1
  glycerate kinase
  integrator complex subunit 5
  mitochondrial ribosomal protein S14
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S23
  mitochondrial ribosomal protein S24
  mitochondrial ribosomal protein S7
  mitotic spindle organizing protein 1
  mitotic spindle organizing protein 1
  mitotic spindle organizing protein 2
  mitotic spindle organizing protein 2A
  mitotic spindle organizing protein 2B
  NEDD1 gamma-tubulin ring complex targeting factor
  NME/NM23 family member 7
  p21 (RAC1) activated kinase 5
  pelota mRNA surveillance and ribosome rescue factor
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 17
  regulation of nuclear pre-mRNA domain containing 1B
  ring finger protein 146
  serine dehydratase like
  SH3 domain containing kinase binding protein 1
  STN1 subunit of CST complex
  thioredoxin domain containing 12
  torsin 1A interacting protein 2
  tubulin alpha 1c
  tubulin beta class I
  tubulin gamma complex associated protein 5
  tubulin gamma complex associated protein 6
  tubulin, gamma 1
  tubulin, gamma complex associated protein 3
  tubulin, gamma complex associated protein 5
  tubulin, gamma complex associated protein 6
  ubiquinol-cytochrome c reductase complex assembly factor 2
  USH1 protein network component harmonin binding protein 1
  V-set and immunoglobulin domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.