HES1, hes family bHLH transcription factor 1

HES1, hes family bHLH transcription factor 1

• This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription factor HES-1, class B basic helix-loop-helix protein 39, hairy homolog, hairy-like protein, HES-1, HHL, HRY, bHLHb39,)
• NCBI Gene ID: 3280
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14469
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hes family bHLH transcription factor 1 interacts with:

• aph-1 homolog A, gamma-secretase subunit
  cullin 1
  FA complementation group L
  F-box and leucine rich repeat protein 14
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 4
  hes family bHLH transcription factor 1
  hes family bHLH transcription factor 6
  hes related family bHLH transcription factor with YRPW motif 1
  hes related family bHLH transcription factor with YRPW motif 2
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 6
  inhibitor of DNA binding 1, HLH protein
  inhibitor of DNA binding 2
  inhibitor of DNA binding 3, HLH protein
  inhibitor of DNA binding 4, HLH protein
  Janus kinase 2
  LIM domain only 3
  lymphotoxin beta receptor
  nescient helix-loop-helix 2
  nudix hydrolase 3
  protein kinase C alpha
  protein tyrosine kinase 2
  recombination signal binding protein for immunoglobulin kappa J region
  RNA polymerase II subunit A
  signal transducer and activator of transcription 3
  sirtuin 1
  spectrin alpha, non-erythrocytic 1
  S-phase kinase associated protein 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  TLE family member 1, transcriptional corepressor
  TLE family member 2, transcriptional corepressor
  TNFAIP3 interacting protein 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquilin 1
  ubiquitin C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.