SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit

SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit

• Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

• Gene Synonyms (FACT complex subunit SPT16, FACT 140 kDa subunit, chromatin-specific transcription elongation factor 140 kDa subunit, facilitates chromatin remodeling 140 kDa subunit, facilitates chromatin transcription complex subunit SPT16, hSPT16, suppressor of Ty 16 homolog, CDC68, FACTP140, SPT16, SPT16/CDC68,)
• NCBI Gene ID: 11198
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y5B9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SPT16 homolog, facilitates chromatin remodeling subunit interacts with:

• agrin
  anoctamin 7
  apoptotic chromatin condensation inducer 1
  aprataxin and PNKP like factor
  ATRX, chromatin remodeler
  autophagy related 16 like 1
  BRCA1/BRCA2-containing complex subunit 3
  bromodomain containing 7
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  centrobin, centriole duplication and spindle assembly protein
  centromere protein Q
  centrosomal protein 164
  centrosomal protein 97
  chromobox 1
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 11A
  cyclin dependent kinase 12
  decapping enzyme, scavenger
  DNA polymerase lambda
  ETAA1 activator of ATR kinase
  eukaryotic translation initiation factor 3, subunit A
  eukaryotic translation initiation factor 3, subunit E
  eukaryotic translation initiation factor 3, subunit I
  F-box and WD repeat domain containing 11
  forty-two-three domain containing 1
  glutamine rich 1
  H2B clustered histone 1
  immunoglobulin superfamily member 8
  interacts with SUPT6H, CTD assembly factor 1
  KRI1 homolog
  L3MBTL histone methyl-lysine binding protein 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  macroH2A.2 histone
  MAF bZIP transcription factor F
  mediator complex subunit 4
  MMS22 like, DNA repair protein
  mono-ADP ribosylhydrolase 1
  myocardin related transcription factor A
  myosin, heavy polypeptide 9, non-muscle
  N-alpha-acetyltransferase 40, NatD catalytic subunit
  Nanog homeobox
  nicastrin
  NIMA related kinase 9
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 5
  PAF1 homolog, Paf1/RNA polymerase II complex component
  pescadillo ribosomal biogenesis factor 1
  pleckstrin homology domain containing A4
  pleckstrin homology domain interacting protein
  POC1 centriolar protein B
  polynucleotide kinase 3'-phosphatase
  PR/SET domain 16
  pre-mRNA processing factor 6
  PTEN induced kinase 1
  pyrin and HIN domain family member 1
  RAD18 E3 ubiquitin protein ligase
  regulation of nuclear pre-mRNA domain containing 1B
  replication protein A4
  ribosomal protein L35
  ring finger and CCCH-type domains 2
  ring finger protein 146
  ring finger protein 20
  RIO kinase 1
  RNA binding motif protein 25
  RNA polymerase I subunit A
  RNA polymerase I subunit E
  RTF1 homolog, Paf1/RNA polymerase II complex component
  signal recognition particle 72
  spindle and centriole associated protein 1
  spindlin family member 2B
  splicing regulatory glutamic acid and lysine rich protein 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  TIMELESS interacting protein
  TNFAIP3 interacting protein 2
  tripartite motif containing 33
  ubiquitin protein ligase E3 component n-recognin 5
  vir like m6A methyltransferase associated
  WD repeat domain 76
  zinc finger CCCH-type containing 18

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.