NCK1, NCK adaptor protein 1

NCK1, NCK adaptor protein 1

• The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

• Gene Synonyms (NCK, NCKalpha, nck-1, cytoplasmic protein NCK1, NCK tyrosine kinase, SH2/SH3 adaptor protein NCK-alpha, melanoma NCK protein, non-catalytic region of tyrosine kinase,)
• NCBI Gene ID: 4690
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16333
  UNIPROT ID#>>A0A0S2Z4Y3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NCK adaptor protein 1 interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  abl interactor 1
  abl interactor 2
  ADAM metallopeptidase domain 15
  adhesion G protein-coupled receptor L2
  adiponectin receptor 2
  B cell linker
  BCAR1 scaffold protein, Cas family member
  BRICK1 subunit of SCAR/WAVE actin nucleating complex
  centrosomal protein 170
  clathrin interactor 1
  copine 5
  cytoplasmic FMR1 interacting protein 2
  DDB1 and CUL4 associated factor 15
  DLG associated protein 4
  docking protein 1
  docking protein 2
  drosha ribonuclease III
  dual specificity phosphatase 12
  embryonal Fyn-associated substrate
  eukaryotic translation initiation factor 2 subunit beta
  eukaryotic translation initiation factor 2B subunit beta
  family with sequence similarity 217 member B
  FCH and mu domain containing endocytic adaptor 1
  fibroblast growth factor receptor substrate 2
  GDP-mannose pyrophosphorylase A
  GRB2 associated binding protein 2
  HEAT repeat containing 3
  homeobox and leucine zipper encoding
  KH RNA binding domain containing, signal transduction associated 1
  KIAA1522
  leucine rich repeat and fibronectin type III domain containing 4
  metastasis associated 1
  metastasis associated 3
  misshapen like kinase 1
  mitogen-activated protein kinase kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 4
  myelin basic protein
  NCK adaptor protein 2
  NCK associated protein 1
  NCK associated protein 5
  NCK interacting protein with SH3 domain
  neural precursor cell expressed, developmentally down-regulated 9
  neurotrophic receptor tyrosine kinase 2
  NHS like 2
  NPHS1 adhesion molecule, nephrin
  NUT family member 2F
  oligodendrocyte transcription factor 1
  p21 (RAC1) activated kinase 1
  p21 (RAC1) activated kinase 2
  p21 (RAC1) activated kinase 3
  paxillin
  phosphoinositide-3-kinase adaptor protein 1
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 1
  platelet derived growth factor receptor beta
  profilin 1
  protein kinase N2
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 12
  Rac family small GTPase 1
  RAD54 like
  Ral GEF with PH domain and SH3 binding motif 1
  Rap guanine nucleotide exchange factor 5
  ras homolog family member U
  RAS p21 protein activator 1
  RAS related
  regulator of telomere elongation helicase 1
  Rho GTPase activating protein 32
  Rho guanine nucleotide exchange factor 7
  Rho/Rac guanine nucleotide exchange factor 2
  SH3 and multiple ankyrin repeat domains 3
  sorbin and SH3 domain containing 3
  SOS Ras/Rac guanine nucleotide exchange factor 1
  spleen associated tyrosine kinase
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 7
  synaptojanin 2
  synaptopodin
  TANK binding kinase 1
  TRAF2 and NCK interacting kinase
  transformation/transcription domain associated protein
  tripartite motif containing 14
  tubulin alpha 1a
  tyrosine kinase non receptor 2
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitously expressed prefoldin like chaperone
  WAS/WASL interacting protein family member 1
  WAS/WASL interacting protein family member 2
  WASP actin nucleation promoting factor
  WASP family member 1
  WASP like actin nucleation promoting factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.