NEDD9, neural precursor cell expressed, developmentally down-regulated 9

NEDD9, neural precursor cell expressed, developmentally down-regulated 9

• The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

• Gene Synonyms (CAS-L, CAS2, CASL, CASS2, HEF1, enhancer of filamentation 1, Cas scaffolding protein family member 2, Crk-associated substrate related protein Cas-L, Enhancer of filamentation 1 p55, cas-like docking, neural precursor cell expressed developmentally down-regulated protein 9, p130Cas-related protein, renal carcinoma antigen NY-REN-12,)
• NCBI Gene ID: 4739
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14511
  UNIPROT ID#>>A0A087WUD2
  UNIPROT ID#>>A0A024QZV9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neural precursor cell expressed, developmentally down-regulated 9 interacts with:

• ankyrin repeat and sterile alpha motif domain containing 1A
  aurora kinase A
  BCAR1 scaffold protein, Cas family member
  BCAR3 adaptor protein, NSP family member
  BTG3 associated nuclear protein
  CDC42 effector protein 2
  chromosome 19 open reading frame 54
  developmental pluripotency associated 4
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DMRT like family B with proline rich C-terminal 1
  epididymal sperm binding protein 1
  exosome component 8
  family with sequence similarity 102 member A
  family with sequence similarity 168 member B
  fizzy and cell division cycle 20 related 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  itchy E3 ubiquitin protein ligase
  kelch like family member 18
  kelch like family member 20
  LIM homeobox 8
  mediator complex subunit 19
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  NBPF member 19
  neural precursor cell expressed, developmentally down-regulated 9
  NFKB inhibitor alpha
  notch 2 N-terminal like A
  notch receptor 3
  paxillin
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphoinositide-3-kinase regulatory subunit 3
  PML-RARA regulated adaptor molecule 1
  proline rich 20A
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 12
  Ras homolog, mTORC1 binding
  regulatory factor X6
  REL proto-oncogene, NF-kB subunit
  RNA binding protein, mRNA processing factor
  SH2 domain containing 3C
  SMAD specific E3 ubiquitin protein ligase 2
  T-box transcription factor 19
  thyroid hormone receptor interactor 6
  TNF receptor associated factor 2
  transcription factor 3
  transcription factor CP2
  tripartite motif containing 27
  vimentin
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  zinc finger protein 76
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.