NFE2L2, nuclear factor, erythroid 2 like 2

NFE2L2, nuclear factor, erythroid 2 like 2

• This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

• Gene Synonyms (HEBP1, IMDDHH, NRF2, Nrf-2, nuclear factor erythroid 2-related factor 2, nuclear factor erythroid-derived 2-like 2,)
• NCBI Gene ID: 4780
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16236
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear factor, erythroid 2 like 2 interacts with:

• beta-transducin repeat containing E3 ubiquitin protein ligase
  cAMP responsive element binding protein 3
  chromodomain helicase DNA binding protein 6
  COP9 signalosome subunit 7A
  cullin 3
  DDB1 and CUL4 associated factor 11
  ectodermal-neural cortex 1
  ETAA1 activator of ATR kinase
  eukaryotic translation initiation factor 2 alpha kinase 3
  F-box and WD repeat domain containing 11
  GADD45G interacting protein 1
  H3 clustered histone 1
  H4 clustered histone 1
  histone deacetylase 3
  kelch like ECH associated protein 1
  kelch-like ECH-associated protein 1
  lysine demethylase 1A
  MAF bZIP transcription factor F
  MAF bZIP transcription factor K
  mitogen-activated protein kinase 7
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase 2
  neutrophil cytosolic factor 1
  neutrophil cytosolic factor 1
  nuclear factor, erythroid 2 like 3
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  peroxisome proliferator activated receptor gamma
  peroxisome proliferator activated receptor gamma
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  polyamine modulated factor 1
  progestin and adipoQ receptor family member 3
  protein kinase C alpha
  protein kinase C delta
  protein phosphatase 1 regulatory subunit 13 like
  ring finger protein 111
  ring finger protein 4
  RNA binding motif protein 45
  RNA binding motif protein X-linked
  sequestosome 1
  siah E3 ubiquitin protein ligase 2
  small ubiquitin like modifier 1
  small ubiquitin like modifier 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  transcription factor 20
  tripartite motif containing 24
  tripartite motif containing 28
  troponin T1, slow skeletal type
  ubiquitin C
  ubiquitin conjugating enzyme E2 E2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin specific peptidase 17 like family member 2
  ubiquitin-conjugating enzyme E2E 1
  WW domain containing adaptor with coiled-coil
  YY1 transcription factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.