SIAH2, siah E3 ubiquitin protein ligase 2

SIAH2, siah E3 ubiquitin protein ligase 2

• This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase SIAH2, RING-type E3 ubiquitin transferase SIAH2, seven in absentia homolog 2, siah-2, hSiah2,)
• NCBI Gene ID: 6478
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43255
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

siah E3 ubiquitin protein ligase 2 interacts with:

• A kinase (PRKA) anchor protein 1
  A-kinase anchoring protein 1
  aldo-keto reductase family 1 member C3
  calcyclin binding protein
  checkpoint kinase 2
  collagen and calcium binding EGF domains 1
  cullin 4B
  dual specificity tyrosine phosphorylation regulated kinase 2
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 2
  egl-9 family hypoxia inducible factor 3
  ELL associated factor 2
  histone deacetylase 3
  homeodomain interacting protein kinase 2
  homeodomain interacting protein kinase 3
  large tumor suppressor kinase 2
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  paternally expressed 10
  phospholipase C epsilon 1
  piwi like RNA-mediated gene silencing 2
  proline rich 20E
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  protein inhibitor of activated STAT 3
  protein phosphatase 1 regulatory subunit 13B
  SET domain containing 2, histone lysine methyltransferase
  SH3 domain containing ring finger 1
  siah E3 ubiquitin protein ligase 2
  signal transducer and activator of transcription 3
  SKI proto-oncogene
  sprouty RTK signaling antagonist 2
  synaptophysin
  synuclein alpha
  synuclein alpha interacting protein
  TERF1 interacting nuclear factor 2
  testin LIM domain protein
  TNF receptor associated factor 2
  TPX2 microtubule nucleation factor
  tumor protein p53 binding protein 2
  tyrosine kinase 2
  tyrosine kinase non receptor 2
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 V2
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 19
  vav guanine nucleotide exchange factor 1
  XIAP associated factor 1
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.