COPS3, COP9 signalosome subunit 3

COPS3, COP9 signalosome subunit 3

• The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

• Gene Synonyms (COP9 signalosome complex subunit 3, COP9 complex subunit 3, COP9 constitutive photomorphogenic homolog subunit 3, JAB1-containing signalosome subunit 3, signalosome subunit 3, CSN3, SGN3,)
• NCBI Gene ID: 8533
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DN01
  UNIPROT ID#>>Q9UNS2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

COP9 signalosome subunit 3 interacts with:

• amyloid beta precursor protein binding family B member 3
  amyloid beta precursor protein binding protein 2
  anterior gradient 2, protein disulphide isomerase family member
  autophagy and beclin 1 regulator 1
  beclin 1
  BTB domain containing 1
  BTB domain containing 2
  centromere protein J
  cereblon
  chromosome 17 open reading frame 75
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 2
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 8
  COP9 signalosome subunit 9
  cullin 1
  cullin 3
  cullin 4A
  damage specific DNA binding protein 1
  DDB1 and CUL4 associated factor 1
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 4 like 2
  DDB1 and CUL4 associated factor 8
  defective in cullin neddylation 1 domain containing 1
  denticleless E3 ubiquitin protein ligase
  denticleless E3 ubiquitin protein ligase homolog
  DET1 and DDB1 associated 1
  DET1 partner of COP1 E3 ubiquitin ligase
  F-box and leucine rich repeat protein 14
  F-box and leucine rich repeat protein 5
  F-box and WD repeat domain containing 7
  F-box protein 17
  F-box protein 6
  F-box protein 7
  fem-1 homolog B
  fibroblast growth factor receptor substrate 3
  flavin adenine dinucleotide synthetase 1
  inhibitor of Bruton tyrosine kinase
  kelch like family member 10
  kelch like family member 15
  kelch like family member 18
  kelch like family member 42
  keratin 80
  lebercilin LCA5
  leucine rich repeat containing 14
  leucine rich repeat protein 1
  leucine rich repeat protein 1
  LRP2 binding protein
  microcephalin 1
  microtubule associated protein 1 light chain 3 alpha
  nucleic acid binding protein 1
  peroxiredoxin like 2B
  pleckstrin homology domain containing A4
  pleckstrin homology domain interacting protein
  polybromo 1
  RecQ like helicase 4
  ring-box 1
  SNW domain containing 1
  splicing factor 3a subunit 3
  suppressor of cytokine signaling 2
  TNF superfamily member 13b
  torsin 1A interacting protein 2
  ubiquitin conjugating enzyme E2 M
  unk zinc finger
  vir like m6A methyltransferase associated
  WD repeat containing, antisense to TP73

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.