PEBP1, phosphatidylethanolamine binding protein 1

PEBP1, phosphatidylethanolamine binding protein 1

• This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

• Gene Synonyms (HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, PBP, PEBP, PEBP-1, RKIP, phosphatidylethanolamine-binding protein 1, Raf kinase inhibitory protein, epididymis luminal protein 210, epididymis secretory protein Li 34, epididymis secretory protein Li 96, hippocampal cholinergic neurostimulating peptide, neuropolypeptide h3, prostatic binding protein, raf kinase inhibitor protein,)
• NCBI Gene ID: 5037
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D9IAI1
  UNIPROT ID#>>P30086
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphatidylethanolamine binding protein 1 interacts with:

• 6-phosphogluconolactonase
  AAR2 splicing factor
  abhydrolase domain containing 11
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily E member 1
  BAG cochaperone 3
  BAG cochaperone 6
  BICD cargo adaptor 2
  cache domain containing 1
  chromosome 11 open reading frame 54
  cytochrome c oxidase assembly factor 4 homolog
  cytochrome c oxidase copper chaperone COX17
  ESF1 nucleolar pre-rRNA processing protein homolog
  gasdermin B
  glucosamine-6-phosphate deaminase 2
  golgin A5
  HNF1 homeobox A
  IQ motif containing B1
  lactate dehydrogenase A like 6A
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  leucine rich repeat kinase 2
  mediator complex subunit 10
  methionine sulfoxide reductase B2
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase kinase 14
  mitogen-activated protein kinase kinase kinase 7
  MLLT11 transcription factor 7 cofactor
  myeloid derived growth factor
  NAD(P) dependent steroid dehydrogenase-like
  NHL repeat containing 2
  NSFL1 cofactor
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  peptidylprolyl isomerase A
  peroxiredoxin 1
  peroxiredoxin 5
  peroxisome proliferator activated receptor delta
  phosphatidylethanolamine binding protein 1
  phosphoethanolamine/phosphocholine phosphatase 1
  poly(A) binding protein cytoplasmic 3
  prostaglandin reductase 1
  protein interacting with PRKCA 1
  protein kinase C alpha
  protein kinase C beta
  protein kinase C delta
  protein kinase C gamma
  protein kinase C zeta
  protein tyrosine phosphatase receptor type D
  RAB26, member RAS oncogene family
  RAB6A, member RAS oncogene family
  Raf-1 proto-oncogene, serine/threonine kinase
  riboflavin kinase
  ribonuclease P and MRP subunit p25
  RNA binding motif protein 10
  sepiapterin reductase
  serine/threonine/tyrosine interacting protein
  SH3 domain binding glutamate rich protein like 3
  signal peptidase complex subunit 2
  sodium channel and clathrin linker 1
  solute carrier family 25 member 32
  stanniocalcin 2
  stress induced phosphoprotein 1
  superoxide dismutase 1
  superoxide dismutase 2
  syntaxin binding protein 2
  taxilin gamma
  thioredoxin domain containing 12
  thiosulfate sulfurtransferase
  TNF receptor associated factor 6
  TP53 regulated inhibitor of apoptosis 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin C-terminal hydrolase L3
  WW domain binding protein 11
  YKT6 v-SNARE homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.