SOD2, superoxide dismutase 2

SOD2, superoxide dismutase 2

• This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]

• Gene Synonyms (superoxide dismutase [Mn], mitochondrial, Mn superoxide dismutase, epididymis secretory sperm binding protein, gastric cancer-associated lncRNA 1, indophenoloxidase B, manganese-containing superoxide dismutase, mangano-superoxide dismutase, superoxide dismutase 2, mitochondrial, GClnc1, IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD,)
• NCBI Gene ID: 6648
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UG59
  UNIPROT ID#>>G5E9P6
  UNIPROT ID#>>Q96AM7
  UNIPROT ID#>>P04179
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

superoxide dismutase 2 interacts with:

• abhydrolase domain containing 10, depalmitoylase
  acetyl-CoA acyltransferase 2
  adenylate kinase 3
  aldehyde dehydrogenase 4 family member A1
  aldehyde dehydrogenase 5 family member A1
  aurora kinase A
  centrosomal protein 70
  cutA divalent cation tolerance homolog
  cytochrome P450 family 4 subfamily F member 12
  destrin, actin depolymerizing factor
  fumarylacetoacetate hydrolase domain containing 2A
  glutamic--pyruvic transaminase 2
  guided entry of tail-anchored proteins factor 4
  haloacid dehalogenase like hydrolase domain containing 2
  HtrA serine peptidase 2
  inorganic pyrophosphatase 2
  isochorismatase domain containing 2
  NFU1 iron-sulfur cluster scaffold
  nucleic acid binding protein 2
  nucleolar protein 12
  peroxiredoxin 5
  pitrilysin metallopeptidase 1
  protein O-glucosyltransferase 3
  RNA exonuclease 2
  succinate-CoA ligase ADP-forming subunit beta
  succinate-CoA ligase GDP/ADP-forming subunit alpha
  superoxide dismutase 2
  syntaxin 7
  thiosulfate sulfurtransferase
  transducin beta like 2
  transketolase
  triosephosphate isomerase 1
  tripartite motif containing 25
  ubiquitin C-terminal hydrolase L3
  ubiquitin like 4A
  ubiquitin protein ligase E3 component n-recognin 2
  ubiquitin specific peptidase 36
  VAMP associated protein A
  zinc finger CCCH-type containing 11A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.