UBR5, ubiquitin protein ligase E3 component n-recognin 5

UBR5, ubiquitin protein ligase E3 component n-recognin 5

• This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase UBR5, E3 identified by differential display, E3 ubiquitin-protein ligase, HECT domain-containing 1, HECT-type E3 ubiquitin transferase UBR5, hyperplastic discs protein homolog, progestin-induced protein, DD5, EDD, EDD1, HYD,)
• NCBI Gene ID: 51366
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95071
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin protein ligase E3 component n-recognin 5 interacts with:

• autophagy and beclin 1 regulator 1
  calreticulin 3
  centromere protein E
  centrosomal protein 78
  centrosomal protein 78
  centrosome and spindle pole associated protein 1
  coiled-coil domain containing 8
  DDB1 and CUL4 associated factor 15
  DEAD-box helicase 28
  developmental pluripotency associated 4
  DExD/H-box helicase 60
  DSN1 component of MIS12 kinetochore complex
  dual specificity phosphatase 26
  ECRG4 augurin precursor
  egl-9 family hypoxia inducible factor 3
  F-box protein 38
  forkhead box J2
  gastrokine 1
  glutamate rich WD repeat containing 1
  heterogeneous nuclear ribonucleoprotein L like
  histone deacetylase 11
  limb development membrane protein 1 like
  lysozyme like 1
  magnesium transporter MRS2
  methyltransferase like 3
  MINDY lysine 48 deubiquitinase 4
  modulator of apoptosis 1
  NLR family pyrin domain containing 3
  OTU deubiquitinase 5
  peter pan homolog
  platelet derived growth factor D
  pleckstrin homology domain containing A4
  prolyl 4-hydroxylase subunit alpha 3
  protein O-glucosyltransferase 1
  pyrin and HIN domain family member 1
  required for meiotic nuclear division 5 homolog A
  ring finger protein 168
  ring finger protein 38
  serine protease 37
  sirtuin 6
  sirtuin 7
  SMU1 DNA replication regulator and spliceosomal factor
  spindle apparatus coiled-coil protein 1
  SprT-like N-terminal domain
  tensin 3
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3 component n-recognin 5
  UTP15 small subunit processome component
  WD repeat domain 48
  X-prolyl aminopeptidase 3
  zinc finger and BTB domain containing 38
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.