PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha

PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha

• cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

• Gene Synonyms (cAMP-dependent protein kinase type I-alpha regulatory subunit, Carney complex type 1, cAMP-dependent protein kinase regulatory subunit RIalpha, cAMP-dependent protein kinase type I-alpha regulatory chain, epididymis secretory sperm binding protein, protein kinase A type 1a regulatory subunit, protein kinase, cAMP-dependent, regulatory subunit type I alpha, protein kinase, cAMP-dependent, regulatory, type I, alpha, tissue-specific extinguisher 1, ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1,)
• NCBI Gene ID: 5573
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P10644
  UNIPROT ID#>>B2R5T5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein kinase cAMP-dependent type I regulatory subunit alpha interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 1
  A kinase (PRKA) anchor protein 7
  actin related protein 2/3 complex subunit 3
  ADP ribosylation factor guanine nucleotide exchange factor 1
  ADP ribosylation factor guanine nucleotide exchange factor 2
  A-kinase anchoring protein 1
  A-kinase anchoring protein 10
  A-kinase anchoring protein 11
  A-kinase anchoring protein 3
  A-kinase anchoring protein 4
  A-kinase anchoring protein 5
  A-kinase anchoring protein 7
  ankyrin repeat domain 26
  argonaute RISC catalytic component 2
  argonaute RISC catalytic component 3
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bromo adjacent homology domain containing 1
  calpain 11
  centrosomal protein 250
  chromosome 11 open reading frame 49
  chromosome 2 open reading frame 88
  coiled-coil domain containing 8
  cullin 3
  cullin 7
  dual specificity tyrosine phosphorylation regulated kinase 1B
  egl-9 family hypoxia inducible factor 3
  exportin 1
  family with sequence similarity 153 member B
  F-box and WD repeat domain containing 8
  FERM domain containing 5
  G protein-coupled receptor 161
  GABA type A receptor associated protein like 1
  glycogen synthase kinase 3 beta
  IQ motif containing B1
  microspherule protein 1
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 6
  NPR2 like, GATOR1 complex subunit
  NUAK family kinase 1
  obscurin like cytoskeletal adaptor 1
  PALM2 and AKAP2 fusion
  pleckstrin homology and FYVE domain containing 2
  POZ/BTB and AT hook containing zinc finger 1
  praja ring finger ubiquitin ligase 2
  pre-mRNA processing factor 31
  pre-mRNA processing factor 40 homolog A
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein kinase cAMP-dependent type I regulatory subunit beta
  protein kinase cAMP-dependent type II regulatory subunit beta
  protein kinase X-linked
  protein kinase, cAMP dependent regulatory, type II alpha
  protein kinase, cAMP dependent, catalytic, beta
  PYD and CARD domain containing
  radial spoke head 3
  Raf-1 proto-oncogene, serine/threonine kinase
  RecQ like helicase 4
  replication factor C subunit 2
  ribosomal RNA processing 1 homolog B (S. cerevisiae)
  ring finger and CCCH-type domains 2
  scaffold attachment factor B
  SET domain containing 7, histone lysine methyltransferase
  SET nuclear proto-oncogene
  SMAD specific E3 ubiquitin protein ligase 1
  solute carrier family 2 member 4
  solute carrier family 38 member 5
  spartin
  sphingosine kinase 2
  SRY-box transcription factor 2
  stomatin like 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  thymidine kinase 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  VAMP associated protein A
  VAMP associated protein B and C
  WD repeat and coiled coil containing
  WNK lysine deficient protein kinase 1
  zinc finger BED-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.