SPP1, secreted phosphoprotein 1

SPP1, secreted phosphoprotein 1

• The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (osteopontin, SPP1/CALPHA1 fusion, early T-lymphocyte activation 1, nephropontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein 1 variant 6, urinary stone protein, uropontin, BNSP, BSPI, ETA-1, OPN,)
• NCBI Gene ID: 6696
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDE2
  UNIPROT ID#>>P10451
  UNIPROT ID#>>Q3LGB0
  UNIPROT ID#>>A0A024RDE6
  UNIPROT ID#>>B7Z351
  UNIPROT ID#>>A0A024RDJ0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

secreted phosphoprotein 1 interacts with:

• AF4/FMR2 family member 4
  agrin
  angiomotin like 2
  ATP binding cassette subfamily F member 3
  BAG cochaperone 6
  bromodomain containing 3
  calcium voltage-gated channel auxiliary subunit gamma 4
  catenin beta like 1
  CDGSH iron sulfur domain 2
  centrosomal protein 162
  chromosome 2 open reading frame 50
  CKLF like MARVEL transmembrane domain containing 3
  coiled-coil and C2 domain containing 1B
  complement C1r subcomponent like
  COP9 signalosome subunit 5
  copper metabolism domain containing 1
  deoxynucleotidyltransferase terminal interacting protein 2
  dermatan sulfate epimerase like
  eukaryotic translation initiation factor 3 subunit K
  GRIP1 associated protein 1
  leucine rich repeat containing 4
  NCK associated protein 1
  neuronal calcium sensor 1
  nicastrin
  PDZ and LIM domain 7
  phosphatidylethanolamine N-methyltransferase
  phospholipase D family member 3
  potassium voltage-gated channel interacting protein 1
  RAN binding protein 9
  Rap guanine nucleotide exchange factor 2
  regulating synaptic membrane exocytosis 4
  SEC24 homolog C, COPII coat complex component
  serine/threonine kinase 39
  small glutamine rich tetratricopeptide repeat containing beta
  small RNA binding exonuclease protection factor La
  SNAP associated protein
  solute carrier family 39 member 6
  staufen double-stranded RNA binding protein 1
  SUZ12 polycomb repressive complex 2 subunit
  TBC1 domain family member 8
  tetratricopeptide repeat domain 1
  TNF receptor associated factor 3
  transmembrane protein 168
  transmembrane protein 30A
  tubulin beta class I
  tumor protein, translationally-controlled 1
  ubiquilin 4
  ubiquitin specific peptidase 42
  ubiquitin specific peptidase 8
  zinc finger protein 638
  zinc finger protein 804A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.