SSB, small RNA binding exonuclease protection factor La

SSB, small RNA binding exonuclease protection factor La

• The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

• Gene Synonyms (lupus La protein, La ribonucleoprotein domain family, member 3, SS-B, SS-B/La protein, Sjogren syndrome antigen B, autoantigen La, la autoantigen, lupus La antigen, sjoegren syndrome type B antigen, LARP3, La, La/SSB,)
• NCBI Gene ID: 6741
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05455
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

small RNA binding exonuclease protection factor La interacts with:

• 2'-5'-oligoadenylate synthetase like
  abl interactor 1
  acidic nuclear phosphoprotein 32 family member A
  ADP ribosylation factor guanine nucleotide exchange factor 1
  ankyrin repeat and MYND domain containing 2
  ariadne RBR E3 ubiquitin protein ligase 2
  armadillo repeat containing 6
  bromodomain containing 7
  BSD domain containing 1
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 8
  chromobox 6
  CLP1, cleavage and polyadenylation factor I subunit
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 4B
  cullin associated and neddylation dissociated 1
  DDB1 and CUL4 associated factor 7
  DEAD-box helicase 27
  DEAD-box helicase 54
  developmental pluripotency-associated 3
  dynamin 1 like
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 3 subunit C
  family with sequence similarity 98 member B
  FANCD2 and FANCI associated nuclease 1
  F-box protein 32
  H3 clustered histone 1
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  integrator complex subunit 3
  integrin alpha FG-GAP repeat containing 1
  kinetochore scaffold 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  lin-28 homolog A
  methylphosphate capping enzyme
  microtubule associated monooxygenase, calponin and LIM domain containing 3
  mitochondrial ribosomal protein L1
  mitotic spindle organizing protein 1
  M-phase phosphoprotein 9
  N-acetyltransferase 10
  NOP56 ribonucleoprotein
  NPL4 homolog, ubiquitin recognition factor
  nuclear receptor subfamily 2 group C member 2
  nucleolar protein interacting with the FHA domain of MKI67
  PAX interacting protein 1
  peptidylprolyl isomerase E
  phosphomevalonate kinase
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  potassium channel modulatory factor 1
  pre-mRNA processing factor 31
  protein tyrosine phosphatase 4A1
  pseudouridine synthase 7
  PTEN induced kinase 1
  RecQ like helicase 4
  ribonuclease P/MRP subunit p38
  RIO kinase 1
  RNA binding motif protein 34
  RNA polymerase I and III subunit C
  scaffold attachment factor B2
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  small RNA binding exonuclease protection factor La
  SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 3
  surfeit 2
  SUZ12 polycomb repressive complex 2 subunit
  TAR DNA binding protein
  TBC1 domain family member 9
  testis expressed 101
  timeless circadian regulator
  transcriptional adaptor 2A
  tripartite motif containing 33
  tRNA methyltransferase 2 homolog A
  tRNA methyltransferase 6
  tropomyosin 2
  tubulin gamma complex associated protein 3
  tumor protein p53
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin like modifier activating enzyme 2
  ubiquitin specific peptidase 15
  VHL binding protein 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  VRK serine/threonine kinase 1
  WD repeat domain 74
  Y box protein 1
  zinc finger protein 593

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.