UVRAG, UV radiation resistance associated

UVRAG, UV radiation resistance associated

• This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

• Gene Synonyms (UV radiation resistance-associated gene protein, beclin 1 binding protein, disrupted in heterotaxy, DHTX, VPS38, p63,)
• NCBI Gene ID: 7405
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P2Y5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

UV radiation resistance associated interacts with:

• AF4/FMR2 family, member 1
  autophagy related 101
  beclin 1
  BRCA1/BRCA2-containing complex subunit 3
  cullin 4A
  exportin 1
  F-box and leucine rich repeat protein 15
  HECT domain E3 ubiquitin protein ligase 1
  phosphoinositide-3-kinase regulatory subunit 4
  RAB7A, member RAS oncogene family
  regulatory associated protein of MTOR complex 1
  ring-box 1
  rubicon autophagy regulator
  rubicon like autophagy enhancer
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 1
  transforming growth factor beta receptor associated protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin specific peptidase 18
  vacuolar protein sorting 4B
  VPS11 core subunit of CORVET and HOPS complexes
  VPS16 core subunit of CORVET and HOPS complexes
  VPS18 core subunit of CORVET and HOPS complexes
  VPS33A core subunit of CORVET and HOPS complexes
  VPS33B late endosome and lysosome associated
  VPS39 subunit of HOPS complex
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.