BECN1, beclin 1

BECN1, beclin 1

• This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Gene Synonyms (beclin-1, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin 1, autophagy related, coiled-coil myosin-like BCL2-interacting protein, testis secretory sperm-binding protein Li 215e, ATG6, VPS30, beclin1,)
• NCBI Gene ID: 8678
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DQ36
  UNIPROT ID#>>E7EV84
  UNIPROT ID#>>A0A024R1X5
  UNIPROT ID#>>W0FFG4
  UNIPROT ID#>>Q14457
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beclin 1 interacts with:

• AFG3 like matrix AAA peptidase subunit 2
  autophagy and beclin 1 regulator 1
  autophagy related 101
  autophagy related 13
  autophagy related 14
  autophagy related 3
  BCL2 like 10
  beclin 1
  chromatin assembly factor 1 subunit A
  DAZ interacting zinc finger protein 3
  DIRAS family GTPase 3
  dishevelled binding antagonist of beta catenin 1
  exocyst complex component 2
  exocyst complex component 4
  exocyst complex component 8
  fibrillarin
  fibroblast growth factor receptor substrate 2
  fizzy and cell division cycle 20 related 1
  GLIS family zinc finger 2
  golgi associated PDZ and coiled-coil motif containing
  HCLS1 associated protein X-1
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  huntingtin interacting protein K
  immunity related GTPase M
  interleukin 24
  itchy E3 ubiquitin protein ligase
  KDEL endoplasmic reticulum protein retention receptor 2
  large tumor suppressor kinase 2
  leucine rich pentatricopeptide repeat containing
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  MAPK activated protein kinase 2
  midasin AAA ATPase 1
  neuroguidin
  NLR family pyrin domain containing 2
  NLR family pyrin domain containing 5
  nuclear receptor binding factor 2
  nuclear RNA export factor 1
  phosphoinositide-3-kinase regulatory subunit 4
  pleckstrin homology domain containing A4
  PTOV1 extended AT-hook containing adaptor protein
  PYD and CARD domain containing
  RB1 inducible coiled-coil 1
  receptor for activated C kinase 1
  ring finger protein 216
  rubicon autophagy regulator
  rubicon like autophagy enhancer
  SAGA complex associated factor 29
  SEH1 like nucleoporin
  septin 11
  sequestosome 1
  serine/threonine kinase 38
  SMAD specific E3 ubiquitin protein ligase 1
  solute carrier family 27 member 4
  sphingosine kinase 1
  Src homology 2 domain containing transforming protein D
  structural maintenance of chromosomes 3
  TBC1 domain family member 7
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  TraB domain containing
  tribbles pseudokinase 1
  tripartite motif containing 16
  tripartite motif containing 50
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 18
  ubiquitin specific peptidase 33
  UV radiation resistance associated gene
  WASH complex subunit 1
  WD repeat domain 81
  WD repeat domain 91
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.