WRN, WRN RecQ like helicase

WRN, WRN RecQ like helicase

• This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

• Gene Synonyms (Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, Werner syndrome RecQ like helicase, Werner syndrome, RecQ helicase-like, exonuclease WRN, recQ protein-like 2, RECQ3, RECQL2, RECQL3,)
• NCBI Gene ID: 7486
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14191
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

WRN RecQ like helicase interacts with:

• checkpoint kinase 2
  chromatin assembly factor 1 subunit A
  DNA polymerase kappa
  DNA polymerase lambda
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  KIAA0930
  mediator of DNA damage checkpoint 1
  MUS81 structure-specific endonuclease subunit
  protection of telomeres 1
  PTTG1 regulator of sister chromatid separation, securin
  RAD54 homolog B
  RNA polymerase I and III subunit C
  sirtuin 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  src kinase associated phosphoprotein 1
  TERF1 interacting nuclear factor 2
  tubulin alpha 1a
  WD repeat domain 48
  WRN helicase interacting protein 1
  WRN RecQ like helicase
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.