MDFI, MyoD family inhibitor

MDFI, MyoD family inhibitor

• This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]

• Gene Synonyms (I-MF, I-mfa, myoD family inhibitor, inhibitor of MyoD family a, myogenic repressor I-mf,)
• NCBI Gene ID: 4188
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B1AKB6
  UNIPROT ID#>>A0A024RCY2
  UNIPROT ID#>>Q99750
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MyoD family inhibitor interacts with:

• 6-phosphogluconolactonase
  abhydrolase domain containing 11
  abhydrolase domain containing 17A, depalmitoylase
  ADAMTS like 3
  adaptor related protein complex 5 subunit zeta 1
  AE binding protein 2
  A-kinase anchoring protein 17A
  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  aminopeptidase like 1
  apelin
  arginine vasopressin induced 1
  armadillo repeat containing 7
  aspartyl aminopeptidase
  ataxin 7 like 2
  ATP binding cassette subfamily F member 3
  AT-rich interaction domain 5A
  autophagy related 12
  axin 1
  BAALC binder of MAP3K1 and KLF4
  BAG cochaperone 3
  BCL6B transcription repressor
  brain expressed X-linked 1
  brain expressed X-linked 2
  brain expressed X-linked 3
  bromo adjacent homology domain containing 1
  BTG3 associated nuclear protein
  calcineurin like EF-hand protein 2
  calcium release activated channel regulator 2A
  cAMP responsive element binding protein 5
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  cation channel sperm associated 1
  CBFA2/RUNX1 partner transcriptional co-repressor 2
  Cbl proto-oncogene like 2
  CDC42 effector protein 1
  cell division cycle 20B
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 7 like
  centrosomal protein 57 like 1
  chromobox 2
  chromobox 8
  chromosome 1 open reading frame 216
  chromosome 10 open reading frame 62
  chromosome 22 open reading frame 39
  chromosome 4 open reading frame 45
  chromosome 8 open reading frame 33
  chromosome 8 open reading frame 48
  chymotrypsin C
  cilia and flagella associated protein 206
  coiled-coil and C2 domain containing 1B
  coiled-coil domain containing 116
  coiled-coil domain containing 120
  coiled-coil domain containing 185
  coiled-coil domain containing 187
  coiled-coil domain containing 198
  coiled-coil domain containing 33
  coiled-coil glutamate rich protein 1
  C-X-C motif chemokine ligand 16
  cyclin and CBS domain divalent metal cation transport mediator 3
  cyclin dependent kinase like 3
  cyclin L2
  cysteine rich hydrophobic domain 2
  DBF4 zinc finger B
  DDB1 and CUL4 associated factor 6
  DDB1 and CUL4 associated factor 8
  DEAD-box helicase 19A
  dehydrogenase/reductase 1
  dendritic cell associated nuclear protein
  dickkopf WNT signaling pathway inhibitor 1
  dishevelled associated activator of morphogenesis 2
  DNA polymerase lambda
  DnaJ heat shock protein family (Hsp40) member B13
  docking protein 3
  doublesex and mab-3 related transcription factor 3
  EGF containing fibulin extracellular matrix protein 2
  elongin A
  enkurin domain containing 1
  Epstein-Barr virus induced 3
  ethanolamine kinase 2
  eukaryotic translation initiation factor 4E family member 2
  FA core complex associated protein 100
  FAM161 centrosomal protein A
  FAM161 centrosomal protein B
  family with sequence similarity 120A opposite strand
  family with sequence similarity 124 member B
  family with sequence similarity 214 member B
  family with sequence similarity 90 member A1
  Fas activated serine/threonine kinase
  fatty acid desaturase 6
  F-box and leucine rich repeat protein 18
  F-box and WD repeat domain containing 5
  F-box protein 34
  FEZ family zinc finger 1
  fibronectin type III domain containing 11
  forkhead box D4 like 1
  forkhead box D4 like 3
  forkhead box D4 like 6
  frizzled class receptor 9
  G protein regulated inducer of neurite outgrowth 2
  general transcription factor IIIC subunit 5
  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  glutaredoxin 3
  G-patch domain and ankyrin repeats 1
  G-patch domain containing 2 like
  gremlin 1, DAN family BMP antagonist
  growth differentiation factor 15
  hes related family bHLH transcription factor with YRPW motif like
  heterogeneous nuclear ribonucleoprotein L like
  histone H3 associated protein kinase
  homeobox A1
  huntingtin interacting protein K
  hyaluronan and proteoglycan link protein 2
  integrator complex subunit 11
  interferon related developmental regulator 2
  IQ motif and ubiquitin domain containing
  Josephin domain containing 1
  KAT8 regulatory NSL complex subunit 1
  kelch like family member 38
  keratin 77
  KIAA0040
  KIAA0408
  late cornified envelope 1A
  late cornified envelope 1B
  late cornified envelope 1D
  late cornified envelope 1F
  late cornified envelope 2B
  late cornified envelope 3A
  late cornified envelope 3C
  late cornified envelope 3D
  late cornified envelope 3E
  late cornified envelope 4A
  leucine rich repeat neuronal 4
  LIM domain only 3
  LIM zinc finger domain containing 2
  lin-7 homolog A, crumbs cell polarity complex component
  lysine acetyltransferase 5
  macrophage immunometabolism regulator
  MAGE family member C3
  MAGE family member D1
  MAGE family member F1
  major facilitator superfamily domain containing 3
  major vault protein
  MAX interactor 1, dimerization protein
  mesenchyme homeobox 2
  methyl-CpG binding domain protein 3 like 2
  methyltransferase like 17
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase binding protein 1
  MUS81 structure-specific endonuclease subunit
  Myb related transcription factor, partner of profilin
  MyoD family inhibitor
  myogenic differentiation 1
  myogenic factor 5
  myogenin
  NADH:ubiquinone oxidoreductase subunit A7
  nectin cell adhesion molecule 2
  neural proliferation, differentiation and control 1
  neuraminidase 4
  NGFI-A binding protein 2
  niban apoptosis regulator 3
  NKD inhibitor of WNT signaling pathway 1
  N-terminal glutamine amidase 1
  nuclear FMR1 interacting protein 2
  nuclear receptor binding SET domain protein 1
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 1 group H member 3
  nucleotide binding protein 2
  odontogenesis associated phosphoprotein
  oligodendrocyte transcription factor 3
  orthodenticle homeobox 1
  outer dense fiber of sperm tails 1
  outer dense fiber of sperm tails 3B
  p53-induced death domain protein 1
  PBX homeobox interacting protein 1
  PDS5 cohesin associated factor A
  pellino E3 ubiquitin protein ligase family member 2
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  PHD finger protein 1
  phenylalanyl-tRNA synthetase 2, mitochondrial
  phosphotyrosine interaction domain containing 1
  PIH1 domain containing 2
  platelet derived growth factor subunit A
  platelet derived growth factor subunit B
  pleckstrin homology and RhoGEF domain containing G4
  pleckstrin homology like domain family A member 1
  poly(ADP-ribose) polymerase family member 11
  polycystin 2, transient receptor potential cation channel
  potassium channel tetramerization domain containing 7
  POZ/BTB and AT hook containing zinc finger 1
  pre-mRNA processing factor 18
  pre-mRNA processing factor 31
  progesterone immunomodulatory binding factor 1
  proprotein convertase subtilisin/kexin type 5
  protein disulfide isomerase family A member 5
  protein kinase AMP-activated non-catalytic subunit beta 2
  protein tyrosine kinase 7 (inactive)
  protein tyrosine phosphatase mitochondrial 1
  RAB, member RAS oncogene family like 6
  Rac family small GTPase 1
  Ras and Rab interactor 1
  ras related dexamethasone induced 1
  receptor transporter protein 5 (putative)
  regenerating family member 3 alpha
  regulatory factor X2
  required for excision 1-B domain containing
  Rho GTPase activating protein 32
  Rhox homeobox family member 2
  ring finger protein 111
  ring finger protein 6
  ripply transcriptional repressor 1
  secretory carrier membrane protein 4
  selenoprotein M
  semaphorin 3B
  serine hydroxymethyltransferase 1
  SET and MYND domain containing 1
  SFI1 centrin binding protein
  shiftless antiviral inhibitor of ribosomal frameshifting
  SIX homeobox 1
  small EDRK-rich factor 2
  sodium channel modifier 1
  solute carrier family 13 member 5
  solute carrier family 15 member 3
  solute carrier family 35 member A2
  solute carrier family 9 member A1
  sorting nexin 18
  spermatogenesis associated 24
  spermatogenesis associated 3
  SPG7 matrix AAA peptidase subunit, paraplegin
  spondin 1
  sprouty related EVH1 domain containing 2
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 2
  sulfite oxidase
  suppressor APC domain containing 2
  suppressor of cytokine signaling 7
  TBC1 domain family member 3B
  TBC1 domain family member 3G
  Tctex1 domain containing 4
  TEA domain transcription factor 4
  testis specific 10 interacting protein
  tetraspanin 4
  tetratricopeptide repeat domain 23
  tetratricopeptide repeat domain 25
  TGFB induced factor homeobox 1
  THAP domain containing 7
  theg spermatid protein
  thioredoxin 2
  TRAF3 interacting protein 2
  transcription activation suppressor family member 2
  transcription elongation factor A N-terminal and central domain containing
  transcription factor 3
  transient receptor potential cation channel subfamily C member 1
  transient receptor potential cation channel subfamily V member 6
  transition protein 2
  translational activator of cytochrome c oxidase I
  transmembrane inner ear
  transmembrane protein 241
  transporter 1, ATP binding cassette subfamily B member
  tribbles pseudokinase 3
  troponin I1, slow skeletal type
  Ts translation elongation factor, mitochondrial
  TSC complex subunit 2
  TSPY like 1
  TSPY like 6
  tubulin epsilon and delta complex 2
  tubulin tyrosine ligase like 10
  tubulointerstitial nephritis antigen like 1
  tumor suppressor 2, mitochondrial calcium regulator
  TYMS opposite strand
  TYRO3 protein tyrosine kinase
  tyrosine hydroxylase
  tyrosine kinase with immunoglobulin like and EGF like domains 1
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 6
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
  vacuolar protein sorting 72 homolog
  vasorin
  vestigial like family member 3
  von Hippel-Lindau tumor suppressor
  V-set and transmembrane domain containing 4
  WD repeat and FYVE domain containing 3
  Wnt family member 11
  yippee like 3
  YY1 transcription factor
  zinc finger and BTB domain containing 24
  zinc finger and BTB domain containing 25
  zinc finger and BTB domain containing 42
  zinc finger and BTB domain containing 9
  zinc finger B-box domain containing
  zinc finger CCCH-type containing, antiviral 1
  zinc finger DHHC-type containing 1
  zinc finger FYVE-type containing 26
  zinc finger HIT-type containing 1
  zinc finger imprinted 2
  zinc finger protein 101
  zinc finger protein 12
  zinc finger protein 124
  zinc finger protein 136
  zinc finger protein 138
  zinc finger protein 155
  zinc finger protein 205
  zinc finger protein 221
  zinc finger protein 223
  zinc finger protein 23
  zinc finger protein 230
  zinc finger protein 264
  zinc finger protein 266
  zinc finger protein 330
  zinc finger protein 408
  zinc finger protein 414
  zinc finger protein 417
  zinc finger protein 426
  zinc finger protein 433
  zinc finger protein 438
  zinc finger protein 439
  zinc finger protein 440
  zinc finger protein 441
  zinc finger protein 446
  zinc finger protein 461
  zinc finger protein 479
  zinc finger protein 490
  zinc finger protein 491
  zinc finger protein 497
  zinc finger protein 512B
  zinc finger protein 524
  zinc finger protein 559
  zinc finger protein 564
  zinc finger protein 572
  zinc finger protein 575
  zinc finger protein 578
  zinc finger protein 580
  zinc finger protein 581
  zinc finger protein 587
  zinc finger protein 607
  zinc finger protein 613
  zinc finger protein 646
  zinc finger protein 648
  zinc finger protein 662
  zinc finger protein 669
  zinc finger protein 670
  zinc finger protein 679
  zinc finger protein 688
  zinc finger protein 696
  zinc finger protein 707
  zinc finger protein 764
  zinc finger protein 784
  zinc finger protein 785
  zinc finger protein 786
  zinc finger protein 79
  zinc finger protein 837
  zinc finger protein 844

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.