SHC1, SHC adaptor protein 1

SHC1, SHC adaptor protein 1

• This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

• Gene Synonyms (SHC-transforming protein 1, SH2 domain protein C1, SHC (Src homology 2 domain containing) transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, SHC, SHCA,)
• NCBI Gene ID: 6464
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P29353
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SHC adaptor protein 1 interacts with:

• AAR2 splicing factor
  apoptosis inducing factor mitochondria associated 1
  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  ATPase family AAA domain containing 3B
  calcium binding and coiled-coil domain 2
  Cbl proto-oncogene C
  CD3 antigen, epsilon polypeptide
  centrosomal protein 170
  chaperonin containing TCP1 subunit 2
  chloride intracellular channel 4
  chromosome 11 open reading frame 58
  coronin 1C
  coronin 2B
  DnaJ heat shock protein family (Hsp40) member A2
  docking protein 2
  dual specificity phosphatase 23
  elongation factor Tu GTP binding domain containing 2
  elongator complex protein 1
  ERBB receptor feedback inhibitor 1
  exportin 1
  ezrin
  family with sequence similarity 118 member B
  gem nuclear organelle associated protein 7
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  GRB2 associated binding protein 2
  GRB2 associated regulator of MAPK1 subtype 1
  GRB2 related adaptor protein
  GRB2 related adaptor protein 2
  GRB2-related adaptor protein 2
  growth factor receptor bound protein 2-associated protein 2
  HCLS1 associated protein X-1
  histone deacetylase 4
  insulin receptor substrate 2
  IQ motif containing GTPase activating protein 1
  keratin 77
  leucine rich repeat kinase 1
  MAPK activated protein kinase 2
  microtubule associated protein 1 light chain 3 alpha
  mitochondrial ribosomal protein L44
  mitogen-activated protein kinase kinase kinase kinase 1
  myosin heavy chain 14
  nuclear RNA export factor 1
  nudix hydrolase 21
  O-sialoglycoprotein endopeptidase
  phospholipid phosphatase 3
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proline-serine-threonine phosphatase interacting protein 2
  protein activator of interferon induced protein kinase EIF2AK2
  protein arginine methyltransferase 5
  protein phosphatase 1 regulatory subunit 9B
  protein tyrosine phosphatase, non-receptor type 12
  pseudopodium enriched atypical kinase 1
  RAB3 GTPase activating non-catalytic protein subunit 2
  RAS protein activator like 2
  regulator of microtubule dynamics 1
  Rho GTPase activating protein 32
  Rho guanine nucleotide exchange factor 5
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  SEC16 homolog A, endoplasmic reticulum export factor
  SH2B adaptor protein 2
  SHC adaptor protein 1
  SHC adaptor protein 2
  SHC binding and spindle associated 1
  signal regulatory protein alpha
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  sodium channel and clathrin linker 1
  SOS Ras/Rac guanine nucleotide exchange factor 1
  SOS Ras/Rho guanine nucleotide exchange factor 2
  Sp1 transcription factor
  spectrin alpha, erythrocytic 1
  spectrin alpha, non-erythrocytic 1
  spectrin beta, non-erythrocytic 1
  spleen associated tyrosine kinase
  SRC proto-oncogene, non-receptor tyrosine kinase
  suppressor of cytokine signaling 5
  suppressor of variegation 3-9 homolog 2
  syntaxin binding protein 1
  tec protein tyrosine kinase
  TEK receptor tyrosine kinase
  translocase of inner mitochondrial membrane 50
  translocated promoter region, nuclear basket protein
  tripartite motif containing 15
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha 4b
  tubulin alpha 8
  tubulin alpha like 3
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  ubiquitin associated and SH3 domain containing B
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 9 X-linked
  ubiquitin specific peptidase 9 Y-linked
  valyl-tRNA synthetase 1
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 3
  WW domain containing E3 ubiquitin protein ligase 2
  YES proto-oncogene 1, Src family tyrosine kinase
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger and BTB domain containing 7A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.