DDX20, DEAD-box helicase 20

DDX20, DEAD-box helicase 20

• DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

• Gene Synonyms (probable ATP-dependent RNA helicase DDX20, DEAD (Asp-Glu-Ala-Asp) box polypeptide 20, DEAD box protein 20, DEAD box protein DP 103, DEAD-box protein DP103, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD, SMN-interacting protein, component of gems 3, gemin-3, DP103, GEMIN3,)
• NCBI Gene ID: 11218
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H4N4
  UNIPROT ID#>>Q9UHI6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 20 interacts with:

• anoctamin 7
  argonaute RISC catalytic component 2
  bromodomain containing 7
  catechol-O-methyltransferase domain containing 1
  cleavage and polyadenylation specific factor 7
  DEAD-box helicase 20
  dicer 1, ribonuclease III
  DNA cross-link repair 1C
  egl-9 family hypoxia inducible factor 3
  ELL associated factor 1
  eukaryotic translation initiation factor 2 alpha kinase 1
  GAR1 ribonucleoprotein
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 5
  gem nuclear organelle associated protein 6
  gem nuclear organelle associated protein 7
  gem nuclear organelle associated protein 8
  glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  GRB10 interacting GYF protein 2
  histone deacetylase 11
  itchy E3 ubiquitin protein ligase
  limb development membrane protein 1 like
  LSM11, U7 small nuclear RNA associated
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  lysine demethylase 6B
  Nanog homeobox
  nuclear assembly factor 1 ribonucleoprotein
  nuclear FMR1 interacting protein 1
  phosphorylated adaptor for RNA export
  pleckstrin homology domain containing A4
  poly(ADP-ribose) polymerase family member 16
  polynucleotide kinase 3'-phosphatase
  potassium channel, subfamily K, member 1
  prohibitin 2
  protein phosphatase 4 regulatory subunit 2
  purinergic receptor P2Y12
  ring finger and CCCH-type domains 2
  RNA polymerase I subunit E
  SIGLEC family like 1
  SIN3 transcription regulator family member A
  sirtuin 7
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein 70 (U1)
  solute carrier family 15 member 3
  survival motor neuron 1
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.