RB1, RB transcriptional corepressor 1

RB1, RB transcriptional corepressor 1

• The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

• Gene Synonyms (retinoblastoma-associated protein, GOS563 exon 17 substitution mutation causes premature stop, exon 17 tumor GOS561 substitution mutation causes premature stop, prepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130, retinoblastoma 1, retinoblastoma suspectibility protein, OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110,)
• NCBI Gene ID: 5925
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDV3
  UNIPROT ID#>>P06400
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RB transcriptional corepressor 1 interacts with:

• anaphase promoting complex subunit 2
  ankyrin repeat and sterile alpha motif domain containing 1A
  apoptosis antagonizing transcription factor
  AT-rich interaction domain 3B
  AT-rich interaction domain 4A
  aurora kinase B
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BAG cochaperone 6
  basonuclin 2
  bromodomain containing 2
  bromodomain containing 4
  bromodomain containing 8
  cell division cycle 16
  cellular repressor of E1A stimulated genes 1
  checkpoint kinase 2
  chromobox 1
  chromobox 3
  chromobox 4
  chromobox 5
  chromosome 3 open reading frame 62
  cyclin A1
  cyclin dependent kinase 13
  cyclin-dependent kinase 2
  cytokine dependent hematopoietic cell linker
  diacylglycerol kinase zeta
  DNA topoisomerase II alpha
  DnaJ heat shock protein family (Hsp40) member A2
  dual specificity tyrosine phosphorylation regulated kinase 1B
  ectodermal-neural cortex 1
  EP300 interacting inhibitor of differentiation 1
  fizzy and cell division cycle 20 related 1
  forkhead box K1
  H4 histone 16
  HECT and RLD domain containing E3 ubiquitin protein ligase 4
  helicase with zinc finger
  high mobility group AT-hook 2
  histone deacetylase 11
  histone deacetylase 3
  HMG-box transcription factor 1
  interferon activated gene 211
  kallikrein related peptidase 11
  L3MBTL histone methyl-lysine binding protein 1
  L3MBTL histone methyl-lysine binding protein 2
  LIM domain binding 1
  lin-37 DREAM MuvB core complex component
  lin-54 DREAM MuvB core complex component
  lin-9 DREAM MuvB core complex component
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine demethylase 2A
  lysine demethylase 4A
  lysine demethylase 5A
  lysine demethylase 5B
  lysine methyltransferase 5C
  mediator complex subunit 23
  meiosis regulator and mRNA stability factor 1
  mitochondrial ribosomal protein S18B
  Morf4 family associated protein 1
  mortality factor 4 like 1
  mortality factor 4 like 2
  NDC80 kinetochore complex component
  nuclear receptor coactivator 6
  paired box 8
  partner of NOB1 homolog
  peter pan homolog
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase A2 group XIIA
  pleckstrin homology domain containing A4
  polycomb group ring finger 3
  PR/SET domain 2
  proline, glutamate and leucine rich protein 1
  protein activator of interferon induced protein kinase EIF2AK2
  protein phosphatase 1 regulatory subunit 26
  RAB GTPase activating protein 1 like
  RAD50 interactor 1
  RB associated KRAB zinc finger
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 5, histone lysine methyltransferase complex subunit
  RB binding protein 6, ubiquitin ligase
  RB binding protein 7, chromatin remodeling factor
  RB binding protein 8, endonuclease
  RB binding protein 9, serine hydrolase
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  receptor for activated C kinase 1
  regulation of nuclear pre-mRNA domain containing 1B
  replication factor C subunit 1
  replication factor C subunit 5
  replication protein A2
  ret finger protein like 2
  ring finger protein 1
  ring finger protein 123
  ring finger protein 4
  ring finger protein 40
  RNA binding motif protein 26
  SET and MYND domain containing 2
  signal transducer and activator of transcription 3
  sirtuin 1
  SKI like proto-oncogene
  SKI proto-oncogene
  small nuclear RNA activating complex polypeptide 1
  small nuclear RNA activating complex polypeptide 3
  SNW domain containing 1
  Sp1 transcription factor
  Sp3 transcription factor
  S-phase kinase associated protein 2
  Spi-1 proto-oncogene
  Spi-B transcription factor
  suppressor of variegation 3-9 homolog 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TATA-box binding protein
  TATA-box binding protein associated factor 1
  THO complex 1
  thymopoietin
  thyroid hormone receptor interactor 11
  TNF receptor associated protein 1
  transcription activation suppressor
  transcription factor 3
  transcription factor AP-2 alpha
  transcription factor Dp family member 3
  transcription factor Dp-1
  transcription factor Dp-2
  transcriptional regulator, SIN3A (yeast)
  transglutaminase 2
  tripartite motif containing 27
  tubulin alpha 1a
  tumor protein p53
  tumor protein p73
  tyrosinase
  ubiquitin conjugating enzyme E2 I
  ubiquitin like 4A
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin specific peptidase 4
  ubiquitin specific peptidase 7
  upstream binding transcription factor
  vascular endothelial growth factor A
  vitamin D receptor
  WEE1 G2 checkpoint kinase
  YY1 transcription factor
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 7A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.