TCP1, t-complex 1

TCP1, t-complex 1

• The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

• Gene Synonyms (T-complex protein 1 subunit alpha, T-complex protein 1, alpha subunit, t-complex 1 protein, tailless complex polypeptide 1, CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha,)
• NCBI Gene ID: 6950
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17987
  UNIPROT ID#>>E7EQR6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

t-complex 1 interacts with:

• AAR2 splicing factor
  actin related protein 2
  actin related protein 3B
  actin, beta
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  angiopoietin like 7
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing 6
  ARP1 actin-related protein 1B, centractin beta
  autophagy related 16 like 1
  B9 domain containing 1
  BCL6 corepressor
  bromodomain containing 7
  BUB3 mitotic checkpoint protein
  CBFA2/RUNX1 partner transcriptional co-repressor 2
  cell division cycle 73
  cereblon
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chaperonin containing Tcp1, subunit 2 (beta)
  chaperonin containing Tcp1, subunit 3 (gamma)
  chaperonin containing Tcp1, subunit 4 (delta)
  chaperonin containing Tcp1, subunit 7 (eta)
  chaperonin containing Tcp1, subunit 8 (theta)
  cilia and flagella associated protein 52
  coiled-coil domain containing 8
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 5
  COPI coat complex subunit gamma 1
  cortactin binding protein 2
  cullin 3
  cullin 7
  DDB1 and CUL4 associated factor 10
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 5
  DDB1 and CUL4 associated factor 7
  DDB1 and CUL4 associated factor 8
  denticleless E3 ubiquitin protein ligase
  derlin 1
  DnaJ heat shock protein family (Hsp40) member A2
  dynein 2 intermediate chain 2
  dynein axonemal intermediate chain 2
  EARP complex and GARP complex interacting protein 1
  EEF1A lysine methyltransferase 3
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  ER lipid raft associated 2
  euchromatic histone lysine methyltransferase 2
  family with sequence similarity 86 member B2
  Fas associated factor 1
  F-box and WD repeat domain containing 8
  F-box protein 25
  F-box protein 46
  F-box protein 6
  F-box protein 7
  FYVE and coiled-coil domain autophagy adaptor 1
  G protein subunit beta 5
  G3BP stress granule assembly factor 1
  gigaxonin
  glucosidase II alpha subunit
  glutamate rich WD repeat containing 1
  GPN-loop GTPase 1
  guanine nucleotide binding protein (G protein), beta 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 3
  histone deacetylase 5
  histone deacetylase 6
  hook microtubule tethering protein 1
  host cell factor C2
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  integrin alpha FG-GAP repeat containing 1
  kelch domain containing 8A
  kelch like family member 33
  kelch repeat and BTB domain containing 4
  kinase suppressor of ras 1
  kinesin family member 21A
  kinesin family member 21B
  L3MBTL histone methyl-lysine binding protein 2
  La ribonucleoprotein 7, transcriptional regulator
  lysine demethylase 4B
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 18
  methyltransferase like 3
  MKS transition zone complex subunit 1
  MOB family member 4, phocein
  NEDD1 gamma-tubulin ring complex targeting factor
  neural precursor cell expressed, developmentally down-regulated gene 1
  neutral sphingomyelinase activation associated factor
  nipsnap homolog 1
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 43
  nucleotide binding oligomerization domain containing 2
  obscurin like cytoskeletal adaptor 1
  osteopetrosis associated transmembrane protein 1
  parkin coregulated
  phosphatidylinositol 4-kinase type 2 beta
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  poly(A) specific ribonuclease subunit PAN2
  polycomb group ring finger 5
  polycomb group ring finger 6
  pre-mRNA processing factor 4
  pre-mRNA processing factor 8
  proteasome 26S subunit, non-ATPase 14
  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  protein phosphatase 2 regulatory subunit Bdelta
  protein phosphatase 4, catalytic subunit
  protein phosphatase 6, catalytic subunit
  protein phosphatase, Mg2+/Mn2+ dependent 1J
  PTEN induced kinase 1
  RAD18 E3 ubiquitin protein ligase
  RAP2C, member of RAS oncogene family
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  ring finger and CCCH-type domains 2
  ring finger and WD repeat domain 3
  ring finger protein 123
  ring finger protein 181
  ring finger protein 31
  RIO kinase 1
  RNA polymerase II associated protein 2
  SAMM50 sorting and assembly machinery component
  SEC31 homolog B, COPII coat complex component
  serine/threonine kinase 24
  serine/threonine kinase 25
  serum/glucocorticoid regulated kinase 2
  SH3 domain binding protein 4
  sirtuin 6
  SMAD specific E3 ubiquitin protein ligase 1
  SNW domain containing 1
  spindle apparatus coiled-coil protein 1
  striatin 3
  striatin, calmodulin binding protein 3
  suppressor of variegation 3-9 homolog 2
  testis specific serine kinase 6
  tetratricopeptide repeat domain 27
  thioredoxin domain containing 9
  THO complex 3
  thymopoietin
  thyroid hormone receptor interactor 4
  TNFAIP3 interacting protein 2
  TRAF3 interacting protein 3
  transcription factor CP2
  transducin beta like 1 Y-linked
  transformed mouse 3T3 cell double minute 2
  tripartite motif containing 28
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha 4a
  tubulin alpha 8
  tubulin alpha like 3
  tubulin gamma 1
  tubulin gamma 2
  tubulin tyrosine ligase like 3
  tubulin tyrosine ligase like 9
  tubulin, alpha 3A
  tubulin, epsilon 1
  tubulin, gamma 1
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine kinase 2
  ubiquilin 2
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin specific peptidase 9 X-linked
  unc-93 homolog B1, TLR signaling regulator
  unk zinc finger
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 2
  VRK serine/threonine kinase 3
  WD and tetratricopeptide repeats 1
  WD repeat containing antisense to TP53
  WD repeat domain 37
  WD repeat domain 48
  WD repeat domain 5
  WD repeat domain 5B
  WD repeat domain 61
  WD repeat domain 77
  WD repeat domain 82
  WD repeat domain 83
  WD repeat domain 86
  WD repeat domain 92
  X-ray repair cross complementing 3
  Yes1 associated transcriptional regulator
  zinc finger FYVE-type containing 21
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.