NNT, nicotinamide nucleotide transhydrogenase

NNT, nicotinamide nucleotide transhydrogenase

• This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]

• Gene Synonyms (NAD(P) transhydrogenase, mitochondrial, pyridine nucleotide transhydrogenase, GCCD4,)
• NCBI Gene ID: 23530
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13423
  UNIPROT ID#>>E9PCX7
  UNIPROT ID#>>A0A024R0C3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nicotinamide nucleotide transhydrogenase interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  armadillo repeat containing X-linked 3
  atlastin GTPase 2
  caveolae associated protein 1
  cell division cycle 26
  chromosome 15 open reading frame 48
  coenzyme Q9
  coiled-coil domain containing 8
  coronin 1C
  ECSIT signaling integrator
  ER membrane protein complex subunit 4
  Fas binding factor 1
  FKBP prolyl isomerase 8
  G protein-coupled receptor class C group 5 member C
  inorganic pyrophosphatase 2
  lactamase beta
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  leucine rich repeat containing 59
  MIS12 kinetochore complex component
  muskelin 1, intracellular mediator containing kelch motifs
  NADH:ubiquinone oxidoreductase core subunit S7
  nei like DNA glycosylase 3
  pentatricopeptide repeat domain 1
  pleckstrin homology domain containing A4
  sirtuin 7
  SLAIN motif family member 2
  sushi domain containing 4
  terminal nucleotidyltransferase 4B
  translocase of inner mitochondrial membrane 10
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.