GIT2, GIT ArfGAP 2

GIT2, GIT ArfGAP 2

• This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

• Gene Synonyms (ARF GTPase-activating protein GIT2, ARF GAP GIT2, G protein-coupled receptor kinase interacting ArfGAP 2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, Paxillin kinase linker, cool-associated, tyrosine phosphorylated protein 2, cool-interacting tyrosine-phosphorylated protein 2, CAT-2, CAT2, PKL,)
• NCBI Gene ID: 9815
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q68DM7
  UNIPROT ID#>>F8VXI9
  UNIPROT ID#>>F8W822
  UNIPROT ID#>>Q14161
  UNIPROT ID#>>Q6FI58
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GIT ArfGAP 2 interacts with:

• activating transcription factor 5
  autophagy related 16 like 1
  calcium binding and coiled-coil domain 2
  caveolae associated protein 1
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 93
  coronin 1A
  dedicator of cytokinesis 5
  enhancer of mRNA decapping 4
  exocyst complex component 1
  F-box protein 28
  GIT ArfGAP 1
  GIT ArfGAP 2
  golgin A5
  GRIP1 associated protein 1
  guided entry of tail-anchored proteins factor 4
  HAUS augmin like complex subunit 6
  heterogeneous nuclear ribonucleoprotein U like 1
  high mobility group 20A
  kelch like family member 2
  MAF bZIP transcription factor F
  major vault protein
  mediator complex subunit 4
  NCK associated protein 5 like
  NCK interacting protein with SH3 domain
  NUF2 component of NDC80 kinetochore complex
  Opa interacting protein 5
  PHD finger protein 21A
  piccolo presynaptic cytomatrix protein
  pleckstrin homology domain containing A4
  pleckstrin homology like domain family B member 3
  potassium channel tetramerization domain containing 5
  protein kinase N3
  quinolinate phosphoribosyltransferase
  RAB GTPase activating protein 1 like
  RAB guanine nucleotide exchange factor 1
  regulation of nuclear pre-mRNA domain containing 1A
  REST corepressor 1
  RNA polymerase I subunit B
  RUN and FYVE domain containing 1
  RUN and SH3 domain containing 2
  SH3 domain containing GRB2 like, endophilin B2
  syncoilin, intermediate filament protein
  TCF3 fusion partner
  THAP domain containing 11
  TNFAIP3 interacting protein 1
  tropomodulin 4
  ubiquilin 1
  USH1 protein network component harmonin binding protein 1
  VPS50 subunit of EARP/GARPII complex
  VPS53 subunit of GARP complex

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.