AATF, apoptosis antagonizing transcription factor

AATF, apoptosis antagonizing transcription factor

• The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein AATF, rb-binding protein Che-1, BFR2, CHE-1, CHE1, DED,)
• NCBI Gene ID: 26574
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NY61
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

apoptosis antagonizing transcription factor interacts with:

• apoptosis antagonizing transcription factor
  biogenesis of ribosomes BRX1
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 56
  decapping enzyme, scavenger
  DNA replication fork stabilization factor DONSON
  ESF1 nucleolar pre-rRNA processing protein homolog
  homeodomain interacting protein kinase 2
  KRI1 homolog
  lin-28 homolog A
  membrane palmitoylated protein 6
  MMS19 homolog, cytosolic iron-sulfur assembly component
  nucleolar protein 10
  nucleolar protein 6
  pleckstrin homology domain containing A4
  pterin-4 alpha-carbinolamine dehydratase 2
  pyrin and HIN domain family member 1
  regulator of telomere elongation helicase 1
  ribosome production factor 2 homolog
  RIO kinase 1
  RuvB-like protein 1
  sirtuin 7
  WD repeat domain 36
  zinc finger protein 324B
  zinc finger protein 468

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.