MDH2, malate dehydrogenase 2

MDH2, malate dehydrogenase 2

• Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

• Gene Synonyms (EIEE51, M-MDH, MDH, MGC:3559, MOR1, malate dehydrogenase, mitochondrial, malate dehydrogenase 2, NAD (mitochondrial), testicular tissue protein Li 120,)
• NCBI Gene ID: 4191
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P40926
  UNIPROT ID#>>A0A024R4K3
  UNIPROT ID#>>B3KTM1
  UNIPROT ID#>>G3XAL0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

malate dehydrogenase 2 interacts with:

• AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  adenylate kinase 3
  anterior gradient 2, protein disulphide isomerase family member
  coactosin like F-actin binding protein 1
  coenzyme Q2, polyprenyltransferase
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  coronin 1C
  cullin 7
  cysteinyl-tRNA synthetase 2, mitochondrial
  DAZ associated protein 1
  derlin 1
  dynamin 1 like
  EEF1A lysine methyltransferase 3
  Fas associated factor 1
  fumarylacetoacetate hydrolase domain containing 1
  glutamate rich WD repeat containing 1
  glutaredoxin 2
  GrpE like 1, mitochondrial
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  lactate dehydrogenase A like 6A
  leucine rich repeat kinase 2
  malate dehydrogenase 2
  methylphosphate capping enzyme
  mitochondrial ribosomal protein S28
  mitogen-activated protein kinase 13
  NADH:ubiquinone oxidoreductase core subunit S1
  neurotrophic receptor tyrosine kinase 1
  nuclear distribution C, dynein complex regulator
  nuclear factor of activated T cells 1
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  peroxiredoxin 1
  peroxiredoxin 5
  phosphoethanolamine/phosphocholine phosphatase 1
  proliferating cell nuclear antigen
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 4
  protein phosphatase methylesterase 1
  PTEN induced kinase 1
  pyruvate carboxylase
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate kinase M1/2
  quiescin sulfhydryl oxidase 2
  RAB10, member RAS oncogene family
  RecQ like helicase 4
  sterol O-acyltransferase 1
  succinate dehydrogenase complex flavoprotein subunit A
  succinate dehydrogenase complex iron sulfur subunit B
  superoxide dismutase 1
  TRAF family member associated NFKB activator
  transcription factor CP2
  translocase of inner mitochondrial membrane 13
  tripartite motif containing 25
  tryptophanyl-tRNA synthetase 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 L3
  ubiquitin C-terminal hydrolase L3
  ubiquitin fold modifier 1
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  Yes1 associated transcriptional regulator
  YKT6 v-SNARE homolog
  Z-DNA binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.