HUWE1, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

HUWE1, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

• This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]

• Gene Synonyms (E3 ubiquitin-protein ligase HUWE1, ARF-binding protein 1, BJ-HCC-24 tumor antigen, HECT domain protein LASU1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, HECT-type E3 ubiquitin transferase HUWE1, Mcl-1 ubiquitin ligase E3, URE-binding protein 1, homologous to E6AP carboxyl terminus homologous protein 9, large structure of UREB1, upstream regulatory element-binding protein 1, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MRXST, MULE, URE-B1, UREB1,)
• NCBI Gene ID: 10075
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z6Z7
  UNIPROT ID#>>A0A024R9W5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 interacts with:

• abraxas 2, BRISC complex subunit
  acidic nuclear phosphoprotein 32 family member B
  actin related protein 1A
  activator of HSP90 ATPase activity 1
  adaptor related protein complex 3 subunit sigma 2
  adhesion regulating molecule 1
  AHNAK nucleoprotein 2
  A-kinase anchoring protein 9
  ankyrin repeat family A member 2
  anterior gradient 2, protein disulphide isomerase family member
  autophagy and beclin 1 regulator 1
  autophagy related 3
  Bet1 golgi vesicular membrane trafficking protein
  biogenesis of lysosomal organelles complex 1 subunit 5
  BRCA1/BRCA2-containing complex subunit 3
  bromodomain containing 7
  capping protein regulator and myosin 1 linker 1
  CD2 associated protein
  CDK5 regulatory subunit associated protein 3
  centrosomal protein 250
  centrosomal protein 78
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromodomain Y like 2
  chromosome 16 open reading frame 72
  chromosome 17 open reading frame 75
  chromosome 18 open reading frame 21
  clusterin associated protein 1
  coiled-coil domain containing 8
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  derlin 1
  developmental pluripotency associated 4
  DNA damage inducible transcript 4
  DNA polymerase lambda
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member C8
  EEF1A lysine methyltransferase 3
  endoplasmic reticulum protein 29
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 3 subunit M
  family with sequence similarity 91 member A1
  Fas associated factor family member 2
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  F-box protein 6
  F-box protein 7
  forkhead box B1
  glucosidase II alpha subunit
  glutamate rich WD repeat containing 1
  glycine N-methyltransferase
  GRB10 interacting GYF protein 2
  guided entry of tail-anchored proteins factor 4
  H2B.U histone 1
  heat shock protein family H (Hsp110) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 11
  KIAA1191
  kinesin family member 13A
  Kruppel like factor 16
  La ribonucleoprotein 7, transcriptional regulator
  LIM and calponin homology domains 1
  limb development membrane protein 1 like
  LSM family member 14B
  LSM12 homolog
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LUC7 like 2, pre-mRNA splicing factor
  lysine demethylase 3A
  mediator complex subunit 4
  methylcrotonoyl-CoA carboxylase 1
  methylcrotonoyl-CoA carboxylase 2
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  methyltransferase like 14
  methyltransferase like 3
  microtubule actin crosslinking factor 1
  microtubule associated protein RP/EB family member 2
  muscle RAS oncogene homolog
  myocardin related transcription factor B
  myosin light chain 6B
  NADH:ubiquinone oxidoreductase subunit A13
  Nanog homeobox
  NCK associated protein 1
  nicalin
  nicotinamide nucleotide transhydrogenase
  NIMA related kinase 9
  nuclear casein kinase and cyclin dependent kinase substrate 1
  nuclear distribution C, dynein complex regulator
  nudix hydrolase 21
  Obg like ATPase 1
  obscurin like cytoskeletal adaptor 1
  PDGFA associated protein 1
  peptidylprolyl isomerase E
  peptidylprolyl isomerase H
  peroxiredoxin 4
  PEST proteolytic signal containing nuclear protein
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
  phosphoglycerate dehydrogenase
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  phosphorylated adaptor for RNA export
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) polymerase alpha
  potassium channel tetramerization domain containing 2
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  prohibitin 2
  proteasome 26S subunit, non-ATPase 14
  proteasome activator subunit 3
  protein disulfide isomerase family A member 6
  protein phosphatase 4 regulatory subunit 3A
  protein tyrosine phosphatase 4A3
  PTEN induced kinase 1
  pyrin and HIN domain family member 1
  rabaptin, RAB GTPase binding effector protein 2
  Ras association domain family member 1
  receptor for activated C kinase 1
  receptor interacting serine/threonine kinase 4
  regulation of nuclear pre-mRNA domain containing 1B
  required for meiotic nuclear division 5 homolog A
  reticulon 4
  ribonuclease P/MRP subunit p30
  ribosomal protein L13a
  ring finger protein 11
  ring finger protein 123
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 2
  SAP30 binding protein
  Sec24 related gene family, member C (S. cerevisiae)
  serine/threonine kinase receptor associated protein
  SERPINE1 mRNA binding protein 1
  sideroflexin 3
  sirtuin 7
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  solute carrier family 15 member 3
  solute carrier family 25 member 19
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3b subunit 3
  SprT-like N-terminal domain
  staphylococcal nuclease and tudor domain containing 1
  SUB1 regulator of transcription
  tensin 2
  tensin 3
  terminal uridylyl transferase 1, U6 snRNA-specific
  testin LIM domain protein
  testis expressed 101
  thioredoxin domain containing 9
  thioredoxin interacting protein
  TOR signaling pathway regulator
  translocase of outer mitochondrial membrane 22
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  tripartite motif containing 28
  tubulin alpha 1c
  tubulin beta 4B class IVb
  tubulin beta class I
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 18
  ubiquitin specific peptidase 49
  ubiquitin specific peptidase 50
  UBX domain protein 1
  unc-45 myosin chaperone A
  unk zinc finger
  UTP23 small subunit processome component
  valosin containing protein (p97)/p47 complex interacting protein 1
  valosin containing protein interacting protein 1
  vir like m6A methyltransferase associated
  WD repeat domain 82
  WD repeat domain 91
  WD repeat domain, phosphoinositide interacting 2
  WW domain binding protein 2
  WW domain containing oxidoreductase
  zinc finger and BTB domain containing 7A
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.