PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3

PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3

• This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with cognitive disability, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

• Gene Synonyms (PAFAHG, platelet-activating factor acetylhydrolase IB subunit gamma, PAF acetylhydrolase 29 kDa subunit, PAF-AH 29 kDa subunit, PAF-AH subunit gamma, PAF-AH1b alpha 1 subunit, PAFAH subunit gamma, epididymis secretory sperm binding protein, platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa), platelet-activating factor acetylhydrolase, isoform Ib, subunit 3 (29kDa),)
• NCBI Gene ID: 5050
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15102
  UNIPROT ID#>>A0A024R0L6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

platelet activating factor acetylhydrolase 1b catalytic subunit 3 interacts with:

• bromodomain containing 7
  charged multivesicular body protein 7
  coiled-coil domain containing 90B
  COP9 signalosome subunit 6
  cullin 7
  DEAD-box helicase 24
  ergosterol biosynthesis 28 homolog
  heat shock protein family H (Hsp110) member 1
  immunoglobin superfamily member 21
  ligand dependent nuclear receptor interacting factor 1
  ligand of numb-protein X 1
  mediator complex subunit 31
  meiotic double-stranded break formation protein 4
  NGG1 interacting factor 3 like 1
  nuclear receptor subfamily 2 group C member 2
  platelet activating factor acetylhydrolase 1b catalytic subunit 3
  platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
  platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
  pleckstrin homology and RUN domain containing M1
  protein interacting with PRKCA 1
  ring finger protein 4
  RNA binding motif protein 48
  RNA transcription, translation and transport factor
  SET domain bifurcated histone lysine methyltransferase 1
  small ubiquitin like modifier 4
  syndecan binding protein 2
  telomeric repeat binding factor 1
  TERF2 interacting protein
  TLE family member 1, transcriptional corepressor
  tubulin beta 2A class IIa
  tumor protein p53
  unc-119 lipid binding chaperone
  valyl-tRNA synthetase 1
  vascular cell adhesion molecule 1
  zinc finger and BTB domain containing 16
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.