TERF1, telomeric repeat binding factor 1

TERF1, telomeric repeat binding factor 1

• This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]

• Gene Synonyms (telomeric repeat-binding factor 1, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, telomeric protein Pin2/TRF1, telomeric repeat binding factor (NIMA-interacting) 1, PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1,)
• NCBI Gene ID: 7013
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P54274
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

telomeric repeat binding factor 1 interacts with:

• 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
  6-phosphogluconolactonase
  ACD shelterin complex subunit and telomerase recruitment factor
  actin filament associated protein 1 like 2
  acyl-CoA thioesterase 7
  AKT interacting protein
  aldo-keto reductase family 1 member A1
  annexin A8 like 1
  BAF chromatin remodeling complex subunit BCL7B
  BAG cochaperone 3
  BAR/IMD domain containing adaptor protein 2 like 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BMP2 inducible kinase
  bridging integrator 2
  bromodomain and WD repeat domain containing 3
  cAMP regulated phosphoprotein 21
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 85
  chromodomain helicase DNA binding protein 8
  chromosome 1 open reading frame 35
  chromosome 12 open reading frame 43
  cilia and flagella associated protein 58
  coiled-coil domain containing 9
  copine 3
  coronin 1B
  cyclin dependent kinase 13
  cytoplasmic FMR1 interacting protein 1
  DEAD-box helicase 19B
  DEAD-box helicase 23
  DEAD-box helicase 24
  DExD-box helicase 21
  DExD-box helicase 39A
  dipeptidyl peptidase 3
  discs large MAGUK scaffold protein 5
  DNA cross-link repair 1B
  drebrin like
  Enah/Vasp-like
  exportin 1
  F-box protein 21
  F-box protein 4
  FKBP prolyl isomerase 8
  forkhead box J3
  G protein nucleolar 3
  G protein nucleolar 3 like
  GIT ArfGAP 1
  glucosidase II alpha subunit
  glycine N-methyltransferase
  GrpE like 1, mitochondrial
  H4 clustered histone 1
  HDGF like 2
  heat shock protein 90 beta family member 1
  heat shock protein family H (Hsp110) member 1
  HEXIM P-TEFb complex subunit 1
  HEXIM P-TEFb complex subunit 2
  high mobility group nucleosomal binding domain 3
  high mobility group nucleosomal binding domain 4
  insulin receptor substrate 4
  junctional sarcoplasmic reticulum protein 1
  kelch domain containing 4
  kelch like ECH associated protein 1
  kinesin family binding protein
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat and sterile alpha motif containing 1
  leucine rich repeat containing 6
  Ly1 antibody reactive
  lysine demethylase 1A
  mediator of DNA damage checkpoint 1
  methylcrotonoyl-CoA carboxylase 2
  microtubule associated protein 7
  microtubule associated protein RP/EB family member 1
  mitochondrial ribosomal protein S9
  mitotic spindle positioning
  mono-ADP ribosylhydrolase 2
  N-acetylglucosamine kinase
  negative regulator of ubiquitin like proteins 1
  neurite extension and migration factor
  NIMA related kinase 7
  nucleolar protein 12
  nucleolar protein 3
  nucleoredoxin like 1
  NudC domain containing 2
  nudix hydrolase 14
  opioid growth factor receptor
  p21 (RAC1) activated kinase 4
  PAGE family member 2
  PCNA clamp associated factor
  peroxiredoxin 4
  peroxiredoxin 6
  phosphoglucomutase 2
  phosphoribosyl pyrophosphate synthetase 1 like 1
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  PIN2 (TERF1) interacting telomerase inhibitor 1
  poly(A) binding protein cytoplasmic 4
  potassium channel tetramerization domain containing 15
  potassium channel tetramerization domain containing 7
  protection of telomeres 1
  protein arginine methyltransferase 5
  protein kinase C and casein kinase substrate in neurons 2
  protein tyrosine phosphatase non-receptor type 5
  RAD50 double strand break repair protein
  Ral GTPase activating protein catalytic subunit alpha 1
  RasGEF domain family member 1C
  RecQ like helicase 4
  reticulon 3
  reticulon 4
  Rho guanine nucleotide exchange factor 3
  Rho/Rac guanine nucleotide exchange factor 18
  RIC8 guanine nucleotide exchange factor A
  ring finger protein 10
  ring finger protein 40
  ring finger protein, LIM domain interacting
  RNA binding motif protein 15B
  RNA binding motif protein 33
  RNA polymerase II associated protein 3
  round spermatid basic protein 1 like
  SAP30 binding protein
  SBDS ribosome maturation factor
  SEC16 homolog A, endoplasmic reticulum export factor
  SH3 domain binding protein 1
  shiftless antiviral inhibitor of ribosomal frameshifting
  signal regulatory protein delta
  spectrin repeat containing nuclear envelope protein 2
  STIP1 homology and U-box containing protein 1
  stromal antigen 1
  SUMO peptidase family member, NEDD8 specific
  T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
  tankyrase
  tankyrase 2
  TATA-box binding protein like 1
  TBC1 domain family member 10A
  telomerase reverse transcriptase
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  TERF1 interacting nuclear factor 2
  TERF2 interacting protein
  THO complex 2
  thymosin beta 10
  thymosin beta 4 Y-linked
  thyroid hormone receptor interactor 10
  TOX high mobility group box family member 4
  transient receptor potential cation channel subfamily C member 5
  transketolase
  translocase of outer mitochondrial membrane 34
  transportin 2
  triosephosphate isomerase 1
  tripartite motif containing 16
  tRNA methyltransferase 1
  tRNA-histidine guanylyltransferase 1 like
  tryptophanyl-tRNA synthetase 1
  tubulin beta 2A class IIa
  tubulin beta 3 class III
  tubulin beta 4B class IVb
  tubulointerstitial nephritis antigen
  tudor domain containing 6
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin specific peptidase 9 X-linked
  UTP14A small subunit processome component
  utrophin
  WD repeat domain 4
  wolframin ER transmembrane glycoprotein
  X-ray repair cross complementing 5
  YY1 transcription factor
  zinc finger and BTB domain containing 16
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing, antiviral 1 like
  zinc finger protein 281
  zinc finger protein 790
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.