TPI1, triosephosphate isomerase 1

TPI1, triosephosphate isomerase 1

• This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

• Gene Synonyms (triosephosphate isomerase, epididymis secretory protein Li 49, methylglyoxal synthase, triose-phosphate isomerase, HEL-S-49, TIM, TPI, TPID,)
• NCBI Gene ID: 7167
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53HE2
  UNIPROT ID#>>P60174
  UNIPROT ID#>>V9HWK1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

triosephosphate isomerase 1 interacts with:

• AAR2 splicing factor
  acidic nuclear phosphoprotein 32 family member E
  acyl-CoA synthetase family member 2
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inducing factor mitochondria associated 1
  aspartyl aminopeptidase
  autophagy related 16 like 1
  cellular repressor of E1A stimulated genes 1
  chloride intracellular channel 4
  chromosome 11 open reading frame 54
  coiled-coil domain containing 8
  copper chaperone for superoxide dismutase
  cullin 1
  cullin 7
  DEAD-box helicase 24
  dehydrogenase/reductase 11
  destrin, actin depolymerizing factor
  dynamin 1 like
  ETHE1 persulfide dioxygenase
  exosome component 5
  ferredoxin 2
  glutamine amidotransferase like class 1 domain containing 3A
  glutathione S-transferase omega 1
  glycerol-3-phosphate dehydrogenase 1 like
  glyoxylate and hydroxypyruvate reductase
  golgi transport 1B
  guanine monophosphate synthase
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histidine triad nucleotide binding protein 2
  histone deacetylase 5
  huntingtin interacting protein K
  IQ motif containing B1
  lactate dehydrogenase A like 6A
  lactate dehydrogenase A like 6B
  leucine rich repeat kinase 2
  lipoyltransferase 1
  mediator complex subunit 20
  multiple inositol-polyphosphate phosphatase 1
  Nanog homeobox
  neudesin neurotrophic factor
  NHL repeat containing 2
  nitrilase family member 2
  obscurin like cytoskeletal adaptor 1
  Parkinsonism associated deglycase
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  peroxiredoxin 6
  phosphoethanolamine/phosphocholine phosphatase 1
  phosphoglucomutase 2
  phosphoglucomutase 2 like 1
  PIH1 domain containing 1
  pre-mRNA processing factor 8
  programmed cell death 6 interacting protein
  protection of telomeres 1
  protein disulfide isomerase family A member 6
  protein O-glucosyltransferase 3
  PTEN induced kinase 1
  pyridoxal kinase
  reactive intermediate imine deaminase A homolog
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  SEC23 interacting protein
  SET domain bifurcated histone lysine methyltransferase 1
  SHANK associated RH domain interactor
  SSU72 homolog, RNA polymerase II CTD phosphatase
  stress induced phosphoprotein 1
  succinate-CoA ligase GDP-forming subunit beta
  SUZ12 polycomb repressive complex 2 subunit
  TAR DNA binding protein
  thioredoxin like 1
  triosephosphate isomerase 1
  tripartite motif containing 25
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 2
  ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  vinculin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.