MAP2K1, mitogen-activated protein kinase kinase 1

MAP2K1, mitogen-activated protein kinase kinase 1

• The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

• Gene Synonyms (dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK 1, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1), CFC3, MAPKK1, MEK1, MEL, MKK1, PRKMK1,)
• NCBI Gene ID: 5604
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DFY5
  UNIPROT ID#>>H3BRW9
  UNIPROT ID#>>A4QPA9
  UNIPROT ID#>>Q02750
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase 1 interacts with:

• ATPase family AAA domain containing 5
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BRCA1 associated protein
  bromodomain containing 4
  BTG3 associated nuclear protein
  centrosomal protein 131
  copine 1
  copine 4
  cullin associated and neddylation dissociated 1
  decapping mRNA 1A
  dynein axonemal heavy chain 1
  filamin, alpha
  heat shock protein family H (Hsp110) member 1
  inhibitor of growth family member 5
  IQ motif containing GTPase activating protein 1
  kinase suppressor of ras 1
  kinase suppressor of ras 1
  kinase suppressor of ras 2
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
  lysine acetyltransferase 7
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase 2
  nuclear FMR1 interacting protein 1
  nuclear receptor subfamily 2 group C member 2
  parvin alpha
  PDZ and LIM domain 5
  perilipin 3
  peroxiredoxin 6
  phosphatidylethanolamine binding protein 4
  phosphoserine aminotransferase 1
  pleckstrin homology and FYVE domain containing 2
  pleckstrin homology domain containing A4
  POC5 centriolar protein
  proteasome 20S subunit alpha 1
  proteasome 20S subunit beta 6
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 14
  protein tyrosine phosphatase non-receptor type 11
  RAB7A, member RAS oncogene family
  Raf-1 proto-oncogene, serine/threonine kinase
  receptor for activated C kinase 1
  ribonuclease A family member 9 (inactive)
  ribosomal protein L10
  ribosomal protein L35a
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein S23
  ribosomal protein S6
  ribosomal protein S6 kinase A2
  ribosomal protein S6 kinase A4
  ribulose-5-phosphate-3-epimerase
  RNA binding motif protein 33
  serine/threonine kinase 11
  snail family transcriptional repressor 1
  spindle and kinetochore associated complex subunit 3
  SRSF protein kinase 1
  t-complex 11
  tectonic family member 1
  THO complex 2
  thymopoietin
  titin
  TNF receptor associated factor 3
  TNF receptor associated factor 6
  tribbles pseudokinase 1
  tripartite motif containing 25
  tumor protein, translationally-controlled 1
  tumor suppressor candidate 3
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L3
  valosin containing protein
  vav guanine nucleotide exchange factor 1
  von Hippel-Lindau tumor suppressor
  WD repeat domain 83
  WNK lysine deficient protein kinase 1
  Yes1 associated transcriptional regulator
  zinc finger protein 277

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.