PSMA1, proteasome 20S subunit alpha 1

PSMA1, proteasome 20S subunit alpha 1

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

• Gene Synonyms (proteasome subunit alpha type-1, 30 kDa prosomal protein, PROS-30, epididymis secretory protein Li 275, macropain subunit C2, macropain subunit nu, multicatalytic endopeptidase complex subunit C2, proteasome (prosome, macropain) subunit, alpha type, 1, proteasome component C2, proteasome nu chain, proteasome subunit alpha 1, proteasome subunit alpha 6, proteasome subunit nu, proteasome subunit, alpha-type, 1, protein P30-33K, testicular tissue protein Li 150, HC2, HEL-S-275, NU, PROS30,)
• NCBI Gene ID: 5682
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P25786
  UNIPROT ID#>>B4E0X6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit alpha 1 interacts with:

• ABI family member 3
  abl interactor 2
  adaptor related protein complex 3 subunit mu 1
  adhesion regulating molecule 1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  anterior gradient 2, protein disulphide isomerase family member
  APAF1 interacting protein
  ATP binding cassette subfamily D member 3
  aurora kinase A
  autophagy and beclin 1 regulator 1
  autophagy related 16 like 1
  BANF family member 2
  basic leucine zipper nuclear factor 1
  calcium binding and coiled-coil domain 2
  calcium binding protein 5
  cell division cycle 23
  centrosomal protein 70
  centrosomal protein 72
  chloride intracellular channel 4
  chromosome 11 open reading frame 49
  chromosome 22 open reading frame 39
  cilia and flagella associated protein 206
  coiled-coil domain containing 102B
  coiled-coil domain containing 136
  coiled-coil domain containing 153
  coiled-coil domain containing 85B
  coilin
  component of oligomeric golgi complex 4
  component of oligomeric golgi complex 6
  COPI coat complex subunit epsilon
  cullin 1
  cullin 4B
  cullin 9
  cyclin dependent kinase 2 interacting protein
  dCTP pyrophosphatase 1
  DEF6 guanine nucleotide exchange factor
  derlin 1
  desumoylating isopeptidase 1
  DNA damage inducible transcript 4 like
  double PHD fingers 2
  DPY30 domain containing 1
  drosha ribonuclease III
  dynactin subunit 2
  dynein light chain Tctex-type 1
  elongation factor Tu GTP binding domain containing 2
  EMSY transcriptional repressor, BRCA2 interacting
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation initiation factor 4A3
  exosome component 4
  exosome component 5
  exosome component 6
  F-box and WD repeat domain containing 8
  F-box protein 6
  F-box protein 7
  fibronectin type III domain containing 11
  FKBP prolyl isomerase 8
  forkhead box K1
  gasdermin D
  gephyrin
  golgin A6 family member A
  GrpE like 1, mitochondrial
  guanylyl cyclase domain containing 1
  heat shock transcription factor 2 binding protein
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  HEXIM P-TEFb complex subunit 2
  homeobox and leucine zipper encoding
  homer scaffold protein 3
  hook microtubule tethering protein 2
  hydroxysteroid 17-beta dehydrogenase 14
  hypoxia up-regulated 1
  IKAROS family zinc finger 1
  IKAROS family zinc finger 3
  importin 13
  INO80 complex subunit E
  interferon induced protein 44 like
  intraflagellar transport 20
  IQ motif containing B1
  IQ motif containing GTPase activating protein 1
  kazrin, periplakin interacting protein
  keratin 37
  keratin 38
  keratin 40
  keratin associated protein 1-1
  keratin associated protein 1-3
  keratin associated protein 4-1
  keratin associated protein 6-3
  KH RNA binding domain containing, signal transduction associated 3
  LDOC1 regulator of NFKB signaling
  leucine rich repeat containing 47
  leucine rich repeat kinase 2
  leucine zipper transcription factor like 1
  leucine zipper tumor suppressor 1
  leucine zipper tumor suppressor 2
  LIM domain binding 1
  limb development membrane protein 1 like
  LON peptidase N-terminal domain and ring finger 1
  lysine demethylase 6B
  makorin ring finger protein 3
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein RP/EB family member 1
  microtubule associated protein RP/EB family member 3
  microtubule associated scaffold protein 2
  midline 2
  mitochondrial elongation factor 1
  mitotic arrest deficient 1 like 1
  Morf4 family associated protein 1 like 1
  Myb/SANT DNA binding domain containing 4 with coiled-coils
  myosin heavy chain 14
  myosin phosphatase Rho interacting protein
  N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
  NBPF member 19
  negative elongation factor complex member E
  NHL repeat containing 2
  NME/NM23 family member 7
  N-myc and STAT interactor
  NOP53 ribosome biogenesis factor
  notch 2 N-terminal like A
  N-terminal EF-hand calcium binding protein 2
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  patched 1
  peptidase M20 domain containing 2
  peptidylprolyl isomerase like 3
  phosphate cytidylyltransferase 2, ethanolamine
  phosphopantothenoylcysteine decarboxylase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PNMA family member 1
  PNMA family member 2
  PNMA family member 5
  potassium channel tetramerization domain containing 1
  potassium channel tetramerization domain containing 13
  potassium channel tetramerization domain containing 17
  potassium channel tetramerization domain containing 6
  potassium channel tetramerization domain containing 7
  potassium channel tetramerization domain containing 9
  PR/SET domain 14
  primase and DNA directed polymerase
  proteasomal ATPase associated factor 1
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 10
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome activator subunit 3 interacting protein 1
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome assembly chaperone 4
  proteasome inhibitor subunit 1
  proteasome maturation protein
  protein interacting with PRKCA 1
  protein phosphatase 4 regulatory subunit 2
  protein tyrosine phosphatase non-receptor type 2
  prothymosin alpha
  RAB1B, member RAS oncogene family
  RAD23 homolog A, nucleotide excision repair protein
  RAD54 homolog B
  RANBP2-type and C3HC4-type zinc finger containing 1
  RecQ like helicase 4
  regulator of G protein signaling 19
  regulatory associated protein of MTOR complex 1
  REL proto-oncogene, NF-kB subunit
  replication factor C subunit 2
  rhophilin associated tail protein 1
  ribonuclease P/MRP subunit p38
  ring finger protein 157
  RNA binding motif protein 28
  RNA polymerase I and III subunit C
  S100 calcium binding protein A4
  SAM pointed domain containing ETS transcription factor
  Scm like with four mbt domains 1
  SEC16 homolog A, endoplasmic reticulum export factor
  Sec23 homolog A, COPII coat complex component
  serine and arginine rich splicing factor 2
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  SH3 domain binding glutamate rich protein like
  SH3 domain binding protein 4
  SH3 domain containing GRB2 like, endophilin B1
  SHANK associated RH domain interactor
  SLX1 homolog B, structure-specific endonuclease subunit
  SMC5-SMC6 complex localization factor 2
  spermidine/spermine N1-acetyltransferase 1
  S-phase kinase associated protein 1
  S-phase kinase-associated protein 1
  SSX family member 2 interacting protein
  structural maintenance of chromosomes 3
  synoviolin 1
  tektin 4
  tenascin R
  thioredoxin interacting protein
  thioredoxin like 1
  TNF alpha induced protein 1
  TNF receptor associated factor 1
  TNF receptor associated factor 5
  transcription factor 12
  transcription factor 4
  transforming growth factor beta 1
  tripartite motif containing 10
  tripartite motif containing 14
  tripartite motif containing 27
  tripartite motif containing 42
  tripartite motif containing 54
  tropomodulin 3
  tropomyosin 4
  tryptophan 2,3-dioxygenase
  TSC22 domain family member 4
  tubulin beta 4B class IVb
  tubulin gamma complex associated protein 3
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 4
  ubiquitin C
  ubiquitin C-terminal hydrolase L5
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  UBX domain protein 1
  UBX domain protein 11
  valosin containing protein
  vimentin
  vimentin type intermediate filament associated coiled-coil protein
  vir like m6A methyltransferase associated
  WD repeat domain 11
  WT1 associated protein
  YES proto-oncogene 1, Src family tyrosine kinase
  yippee like 5
  zinc finger AN1-type containing 1
  zinc finger AN1-type containing 5
  zinc finger CCHC-type containing 8
  zinc finger containing ubiquitin peptidase 1
  zinc finger MYND-type containing 19
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger RANBP2-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.