PSMB6, proteasome 20S subunit beta 6

PSMB6, proteasome 20S subunit beta 6

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

• Gene Synonyms (proteasome subunit beta type-6, PSY large multifunctional protease Y, macropain delta chain, multicatalytic endopeptidase complex delta chain, proteasome (prosome, macropain) subunit, beta type, 6, proteasome catalytic subunit 1, proteasome delta chain, proteasome subunit Y, proteasome subunit beta 6, proteasome subunit beta1, proteasome subunit delta, DELTA, LMPY, Y,)
• NCBI Gene ID: 5694
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IAT9
  UNIPROT ID#>>A0A087X2I4
  UNIPROT ID#>>P28072
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit beta 6 interacts with:

• 5'-3' exoribonuclease 2
  adhesion regulating molecule 1
  alanyl-tRNA synthetase 2, mitochondrial
  anterior gradient 2, protein disulphide isomerase family member
  cell division cycle 73
  cleavage and polyadenylation specific factor 2
  C-type lectin domain containing 14A
  cullin 1
  cysteinyl-tRNA synthetase 2, mitochondrial
  cytochrome c oxidase assembly factor COX16
  derlin 1
  dynactin subunit 2
  elongator acetyltransferase complex subunit 6
  ERBB receptor feedback inhibitor 1
  F-box and WD repeat domain containing 8
  F-box protein 7
  HEXIM P-TEFb complex subunit 1
  IQ motif containing B1
  L3MBTL histone methyl-lysine binding protein 1
  L3MBTL histone methyl-lysine binding protein 4
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing 47
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  mitochondrial ribosomal protein L27
  mitochondrial ribosomal protein L33
  mitochondrial ribosomal protein S11
  NADPH dependent diflavin oxidoreductase 1
  negative elongation factor complex member E
  NHL repeat containing 2
  nuclear distribution C, dynein complex regulator
  obscurin like cytoskeletal adaptor 1
  phosphopantothenoylcysteine synthetase
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  programmed cell death 4
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 10
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 4
  proteasome assembly chaperone 2
  proteasome maturation protein
  RAD23 homolog A, nucleotide excision repair protein
  RecQ like helicase 4
  ribosomal protein L35
  small nuclear ribonucleoprotein polypeptide G
  S-phase kinase associated protein 1
  S-phase kinase-associated protein 1
  SUMO1 activating enzyme subunit 1
  superoxide dismutase 1
  synoviolin 1
  treacle ribosome biogenesis factor 1
  tripartite motif containing 14
  tubulin alpha 1a
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 7
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  VPS16 core subunit of CORVET and HOPS complexes
  zinc finger CCHC-type containing 8
  zinc finger protein 574
  zinc finger protein 830

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.