MAP2K7, mitogen-activated protein kinase kinase 7

MAP2K7, mitogen-activated protein kinase kinase 7

• The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Gene Synonyms (dual specificity mitogen-activated protein kinase kinase 7, JNK-activating kinase 2, MAP kinase kinase 7, MAPK/ERK kinase 7, SAPK kinase 4, c-Jun N-terminal kinase kinase 2, stress-activated protein kinase kinase 4, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4,)
• NCBI Gene ID: 5609
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DV95
  UNIPROT ID#>>O14733
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase 7 interacts with:

• ADAM metallopeptidase domain 32
  ANTXR cell adhesion molecule 1
  autophagy related 16 like 1
  BCL10 immune signaling adaptor
  CASP8 and FADD like apoptosis regulator
  connector enhancer of kinase suppressor of Ras 1
  delta like non-canonical Notch ligand 1
  dual specificity phosphatase 19
  dual specificity phosphatase 22
  dual specificity phosphatase 22
  envoplakin
  exportin 1
  F-box protein 6
  ILK associated serine/threonine phosphatase
  kinesin light chain 2
  leucine rich repeat kinase 2
  leupaxin
  listerin E3 ubiquitin protein ligase 1
  lysosomal associated membrane protein 3
  mitogen-activated protein kinase 8 interacting protein 1
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 12
  mitogen-activated protein kinase kinase kinase 13
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 20
  mitogen-activated protein kinase kinase kinase 7
  pleckstrin homology domain containing A4
  progesterone receptor membrane component 1
  proline dehydrogenase 1
  prostaglandin I2 receptor
  protein Z, vitamin K dependent plasma glycoprotein
  protocadherin gamma subfamily A, 5
  RAN binding protein 2
  ribosomal protein L30
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A2
  SMC hinge domain containing 1
  SNW domain containing 1
  sperm acrosome associated 1
  TNF receptor associated factor 6
  tribbles pseudokinase 1
  two pore segment channel 2
  VRK serine/threonine kinase 2
  V-set and immunoglobulin domain containing 4
  WD repeat domain 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.