RPS6KA1, ribosomal protein S6 kinase A1

RPS6KA1, ribosomal protein S6 kinase A1

• This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ribosomal protein S6 kinase alpha-1, 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, RSK-1, S6K-alpha 1, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1), p90-RSK 1, p90RSK1, p90S6K, ribosomal S6 kinase 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1, HU-1, MAPKAPK1, MAPKAPK1A, RSK, RSK1, p90Rsk,)
• NCBI Gene ID: 6195
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15418
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribosomal protein S6 kinase A1 interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 1
  adaptor related protein complex 3 subunit mu 1
  adaptor related protein complex 4 subunit beta 1
  ALG5 dolichyl-phosphate beta-glucosyltransferase
  aminopeptidase puromycin sensitive
  calcium regulated heat stable protein 1
  carnosine dipeptidase 2
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 45
  chaperonin containing TCP1 subunit 4
  COPI coat complex subunit gamma 1
  DEAH-box helicase 40
  dedicator of cytokinesis 4
  DEP domain containing MTOR interacting protein
  DExD-box helicase 50
  dimethylarginine dimethylaminohydrolase 2
  DLC1 Rho GTPase activating protein
  DNA polymerase delta interacting protein 3
  DnaJ heat shock protein family (Hsp40) member C11
  erbb2 interacting protein
  eukaryotic elongation factor 2 kinase
  eukaryotic translation initiation factor 4H
  family with sequence similarity 136 member A
  fibroblast growth factor receptor substrate 2
  GINS complex subunit 2
  golgi associated PDZ and coiled-coil motif containing
  golgi reassembly stacking protein 1
  golgi reassembly stacking protein 2
  Grid2 interacting protein
  ILK associated serine/threonine phosphatase
  immunity related GTPase cinema
  interleukin 17 receptor A
  inverted formin 2
  isoprenylcysteine carboxyl methyltransferase
  kynureninase
  L antigen family member 3
  ligand of numb-protein X 1
  lipase maturation factor 2
  listerin E3 ubiquitin protein ligase 1
  lysine acetyltransferase 7
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  membrane associated guanylate kinase, WW and PDZ domain containing 2
  membrane associated guanylate kinase, WW and PDZ domain containing 3
  microtubule associated serine/threonine kinase 1
  microtubule associated serine/threonine kinase 2
  microtubule associated serine/threonine kinase like
  mitochondrial poly(A) polymerase
  mitotic spindle positioning
  MORC family CW-type zinc finger 3
  nicalin
  non-SMC condensin II complex subunit G2
  nuclear receptor subfamily 4 group A member 3
  par-3 family cell polarity regulator beta
  PDZ domain containing 7
  PDZ domain containing ring finger 3
  PDZ domain containing ring finger 4
  phosphorylated adaptor for RNA export
  pleckstrin homology domain containing A4
  programmed cell death 4
  protein phosphatase 1 regulatory subunit 9A
  protein phosphatase, Mg2+/Mn2+ dependent 1F
  regulatory associated protein of MTOR complex 1
  Rho guanine nucleotide exchange factor 11
  Rho guanine nucleotide exchange factor 12
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A2
  ribosomal protein S6 kinase A3
  serine and arginine rich splicing factor 5
  serum response factor
  SH3 and multiple ankyrin repeat domains 3
  SLC9A3 regulator 2
  sodium channel and clathrin linker 1
  solute carrier family 16 member 1
  sorting nexin 27
  spleen associated tyrosine kinase
  synaptojanin 2 binding protein
  syntrophin alpha 1
  syntrophin beta 1
  syntrophin beta 2
  syntrophin gamma 2
  telomere maintenance 2
  tousled like kinase 2
  trafficking regulator and scaffold protein tamalin
  transducer of ERBB2, 1
  transducer of ERBB2, 2
  transmembrane protein 97
  transporter 1, ATP binding cassette subfamily B member
  TSC complex subunit 1
  TSC complex subunit 2
  TTK protein kinase
  tubulin beta 3 class III
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquitin conjugating enzyme E2 T
  ubiquitin protein ligase E3 component n-recognin 5
  valosin containing protein
  VPS52 subunit of GARP complex
  whirlin

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