PSMB9, proteasome 20S subunit beta 9

PSMB9, proteasome 20S subunit beta 9

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]

• Gene Synonyms (proteasome subunit beta type-9, large multifunctional peptidase 2, low molecular mass protein 2, macropain chain 7, multicatalytic endopeptidase complex chain 7, proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2), proteasome catalytic subunit 1i, proteasome chain 7, proteasome subunit beta 6i, proteasome subunit beta 9, proteasome subunit beta-1i, proteasome subunit beta1i, proteasome-related gene 2, really interesting new gene 12 protein, LMP2, PRAAS3, PSMB6i, RING12, beta1i,)
• NCBI Gene ID: 5698
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A1U9X8D7
  UNIPROT ID#>>P28065
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit beta 9 interacts with:

• DNA damage inducible transcript 4 like
  elongin A
  F-box protein 7
  G3BP stress granule assembly factor 2
  L antigen family member 3
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor coactivator 3
  nucleolar and coiled-body phosphoprotein 1
  obscurin like cytoskeletal adaptor 1
  oxidative stress responsive serine rich 1
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 10
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome activator subunit 3 interacting protein 1
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome assembly chaperone 4
  proteasome inhibitor subunit 1
  proteasome maturation protein
  Raf-1 proto-oncogene, serine/threonine kinase
  ring finger protein 181
  semenogelin 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  syntaxin 5
  tropomyosin 2
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.