PSMC1, proteasome 26S subunit, ATPase 1

PSMC1, proteasome 26S subunit, ATPase 1

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]

• Gene Synonyms (26S proteasome regulatory subunit 4, 26S protease regulatory subunit 4, 26S proteasome AAA-ATPase subunit RPT2, proteasome (prosome, macropain) 26S subunit, ATPase, 1, proteasome 26S ATPase subunit 1, P26S4, S4, p56,)
• NCBI Gene ID: 5700
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53XL8
  UNIPROT ID#>>P62191
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 26S subunit, ATPase 1 interacts with:

• 5'-3' exoribonuclease 1
  adhesion regulating molecule 1
  aldehyde dehydrogenase 1 family member L1
  aldo-keto reductase family 7 member A2
  ataxin 7
  ATPase H+ transporting V1 subunit D
  autophagy and beclin 1 regulator 1
  autophagy related 4C cysteine peptidase
  BAG cochaperone 3
  CCR4-NOT transcription complex subunit 7
  cell cycle and apoptosis regulator 2
  centrosomal protein 83
  choline/ethanolamine phosphotransferase 1
  coiled-coil domain containing 74B
  coiled-coil domain containing 8
  coiled-coil domain containing 85B
  coiled-coil domain containing 92
  COP9 signalosome subunit 2
  cullin 3
  desumoylating isopeptidase 1
  dpy-30 histone methyltransferase complex regulatory subunit
  dynactin subunit 2
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  Fas associated factor 1
  F-box protein 25
  F-box protein 6
  F-box protein 7
  FKBP prolyl isomerase 8
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  hook microtubule tethering protein 1
  jumonji domain containing 1C
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  L3MBTL histone methyl-lysine binding protein 1
  L3MBTL histone methyl-lysine binding protein 4
  La ribonucleoprotein 7, transcriptional regulator
  LEO1 homolog, Paf1/RNA polymerase II complex component
  ligand of numb-protein X 1
  limb development membrane protein 1 like
  lysine demethylase 1A
  lysine demethylase 6B
  MAGE family member A2B
  methylphosphate capping enzyme
  methyltransferase like 17
  methyltransferase like 3
  midnolin
  MIF4G domain containing
  mitochondrial carrier 1
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L57
  mitochondrial ribosomal protein S16
  mitochondrial ribosomal protein S21
  mitochondrial ribosomal protein S5
  mortality factor 4 like 1
  neuralized E3 ubiquitin protein ligase 4
  NSFL1 cofactor
  nuclear receptor coactivator 4
  nuclear receptor subfamily 2 group C member 2
  pleckstrin homology domain containing A4
  potassium channel modulatory factor 1
  programmed cell death 4
  proteasomal ATPase associated factor 1
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  protein inhibitor of activated STAT 3
  protein tyrosine phosphatase non-receptor type 2
  RAD21 cohesin complex component
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RecQ like helicase 4
  ribophorin I
  ribosomal protein S13
  ribosomal protein S15a
  ribosomal protein S21
  ribosomal protein S6 kinase B2
  ribosomal protein S8
  ring finger protein 123
  RIO kinase 1
  RuvB-like protein 1
  SEM1 26S proteasome complex subunit
  serine/arginine repetitive matrix 2
  snail family transcriptional repressor 1
  snail family transcriptional repressor 2
  SNW domain containing 1
  sorting nexin 12
  spindle and kinetochore associated complex subunit 1
  splicing factor 3a subunit 1
  stathmin 2
  staufen double-stranded RNA binding protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  superoxide dismutase 1
  suppressor of variegation 3-9 homolog 1
  TATA-box binding protein associated factor 2
  thioredoxin like 1
  TNF receptor associated factor 6
  TNFAIP3 interacting protein 2
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  transforming growth factor beta receptor 2
  tripartite motif containing 28
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquilin 2
  ubiquilin 4
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 44
  UDP-glucose glycoprotein glucosyltransferase 1
  vacuolar protein sorting 13 homolog D
  valosin containing protein
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  zinc finger and BTB domain containing 8A
  zinc finger FYVE-type containing 21
  zinc finger protein 561
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.