PSMD11, proteasome 26S subunit, non-ATPase 11

PSMD11, proteasome 26S subunit, non-ATPase 11

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

• Gene Synonyms (26S proteasome non-ATPase regulatory subunit 11, 26S proteasome regulatory subunit 9, 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p44.5, proteasome (prosome, macropain) 26S subunit, non-ATPase, 11, Rpn6, S9, p44.5,)
• NCBI Gene ID: 5717
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00231
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 26S subunit, non-ATPase 11 interacts with:

• adhesion regulating molecule 1
  ankyrin repeat and SOCS box containing 11
  autophagy related 9A
  BRCA1 associated protein 1
  bromodomain containing 7
  coiled-coil domain containing 74B
  coiled-coil domain containing 90B
  coiled-coil domain containing 92
  coiled-coil serine rich protein 2
  COP9 signalosome subunit 2
  COP9 signalosome subunit 3
  COP9 signalosome subunit 6
  cullin 7
  cytochrome c oxidase subunit 5A
  derlin 1
  desumoylating isopeptidase 1
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A4
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 3
  elongator complex protein 1
  FANCD2 and FANCI associated nuclease 1
  F-box protein 25
  FKBP prolyl isomerase 8
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  huntingtin associated protein 1
  immunoglobin superfamily member 21
  insulin induced gene 2
  KDEL endoplasmic reticulum protein retention receptor 1
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  ligand dependent nuclear receptor interacting factor 1
  limb development membrane protein 1 like
  mediator complex subunit 31
  methylphosphate capping enzyme
  midline 2
  mitochondrial carrier 1
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  NLR family pyrin domain containing 9
  obscurin like cytoskeletal adaptor 1
  patched 1
  pleckstrin homology domain containing A4
  pleiotrophin
  potassium channel modulatory factor 1
  prostaglandin E synthase 3
  proteasomal ATPase associated factor 1
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 6
  proteasome activator subunit 3
  protein arginine methyltransferase 6
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type K
  protein tyrosine phosphatase receptor type M
  protein tyrosine phosphatase receptor type O
  pseudouridine synthase 1
  RAD23 homolog A, nucleotide excision repair protein
  RecQ like helicase 4
  ribosomal protein S15a
  ribosomal protein S21
  ribosomal protein S8
  ring finger and CCCH-type domains 1
  ring finger protein 11
  ring finger protein 168
  RNA binding motif protein 48
  SEM1 26S proteasome complex subunit
  SET domain bifurcated histone lysine methyltransferase 1
  SLX1 homolog B, structure-specific endonuclease subunit
  SNW domain containing 1
  sodium leak channel, non-selective
  solute carrier family 17 member 2
  solute carrier organic anion transporter family member 6A1
  SUN domain containing ossification factor
  superoxide dismutase 1
  TLE family member 1, transcriptional corepressor
  TNFAIP3 interacting protein 2
  torsin A interacting protein 1
  transforming growth factor beta receptor 2
  transmembrane channel like 7
  tubulin beta 2A class IIa
  tumor protein p53
  ubiquilin 2
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 4
  unc-119 lipid binding chaperone
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  WD repeat domain, phosphoinositide interacting 2
  zinc finger and BTB domain containing 16
  zinc finger FYVE-type containing 27
  zinc finger protein 598, E3 ubiquitin ligase
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.