STAT1, signal transducer and activator of transcription 1

STAT1, signal transducer and activator of transcription 1

• The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]

• Gene Synonyms (signal transducer and activator of transcription 1-alpha/beta, signal transducer and activator of transcription 1, 91kD, signal transducer and activator of transcription 1, 91kDa, transcription factor ISGF-3 components p91/p84, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91,)
• NCBI Gene ID: 6772
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P42224
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal transducer and activator of transcription 1 interacts with:

• activator of HSP90 ATPase activity 1
  autophagy related 16 like 1
  autophagy related 7
  BPI fold containing family B member 3
  catenin beta like 1
  coiled-coil domain containing 8
  cullin 4B
  cullin associated and neddylation dissociated 1
  C-X-C motif chemokine receptor 4
  cytokine induced apoptosis inhibitor 1
  DDB1 and CUL4 associated factor 13
  dedicator of cytokinesis 4
  deltex E3 ubiquitin ligase 3L
  developmental pluripotency-associated 3
  DOT1 like histone lysine methyltransferase
  elongator acetyltransferase complex subunit 2
  epidermal growth factor receptor
  eukaryotic translation initiation factor 1A domain containing
  exportin 1
  Fas associated via death domain
  F-box and WD repeat domain containing 7
  G1 to S phase transition 2
  G3BP stress granule assembly factor 1
  H2B clustered histone 11
  H3 clustered histone 14
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 4 like
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HIRA interacting protein 3
  histone deacetylase 3
  histone deacetylase 4
  interferon regulatory factor 9
  interleukin 27 receptor subunit alpha
  ISG15 ubiquitin like modifier
  Janus kinase 1
  Janus kinase 2
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  karyopherin subunit alpha 6
  leucine zipper like transcription regulator 1
  mitochondrial antiviral signaling protein
  MTOR associated protein, LST8 homolog
  N-alpha-acetyltransferase 10, NatA catalytic subunit
  N-alpha-acetyltransferase 15, NatA auxiliary subunit
  NMD3 ribosome export adaptor
  N-myc and STAT interactor
  NODAL modulator 1
  NODAL modulator 2
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 1 group H member 3
  nuclear receptor subfamily 2 group C member 2
  OTU deubiquitinase 4
  phosphoglycerate dehydrogenase
  pleckstrin homology domain containing A4
  poly(ADP-ribose) polymerase family member 9
  protein arginine methyltransferase 3
  protein inhibitor of activated STAT 1
  receptor for activated C kinase 1
  ribosomal protein S6 kinase A5
  ring finger protein 11
  RTF1 homolog, Paf1/RNA polymerase II complex component
  SH3 and multiple ankyrin repeat domains 1
  signal regulatory protein alpha
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 2
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 4
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 4
  sorting nexin 6
  sperm acrosome associated 1
  spleen associated tyrosine kinase
  staufen double-stranded RNA binding protein 1
  testin LIM domain protein
  testis expressed 101
  testis expressed 264, ER-phagy receptor
  TNF alpha induced protein 3
  TNF receptor superfamily member 1A
  TNF receptor superfamily member 1B
  TNFRSF1A associated via death domain
  transforming growth factor beta 1
  transforming growth factor beta receptor 2
  translin associated factor X
  tripartite motif containing 11
  tripartite motif containing 28
  tubulin folding cofactor D
  tyrosine kinase 2
  tyrosine kinase non receptor 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 2
  valosin containing protein
  vitamin D receptor
  VPS26, retromer complex component A
  VPS29 retromer complex component
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger protein 467

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.