HSP90B1, heat shock protein 90 beta family member 1

HSP90B1, heat shock protein 90 beta family member 1

• This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

• Gene Synonyms (endoplasmin, 94 kDa glucose-regulated protein, endothelial cell (HBMEC) glycoprotein, epididymis luminal protein 35, epididymis secretory sperm binding protein Li 125m, heat shock protein 90 kDa beta member 1, heat shock protein 90kDa beta (Grp94), member 1, heat shock protein 90kDa beta family member 1, stress-inducible tumor rejection antigen gp96, tumor rejection antigen (gp96) 1, tumor rejection antigen 1, ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1,)
• NCBI Gene ID: 7184
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P14625
  UNIPROT ID#>>V9HWP2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein 90 beta family member 1 interacts with:

• AAR2 splicing factor
  adenylate kinase 9
  agrin
  aldehyde dehydrogenase 1 family member L1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  anterior gradient 2, protein disulphide isomerase family member
  autophagy related 16 like 1
  bone morphogenetic protein receptor, type 1A
  calcyclin binding protein
  calmodulin-like 3
  calreticulin 3
  cell division cycle 37 like 1
  cell division cycle 73
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chromosome 15 open reading frame 39
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  coronin 1C
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclase associated actin cytoskeleton regulatory protein 1
  cytochrome c oxidase subunit 5A
  cytochrome c oxidase subunit 7A2 like
  derlin 1
  dynamin 1 like
  EBP cholestenol delta-isomerase
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  endoplasmic reticulum lectin 1
  ER degradation enhancing alpha-mannosidase like protein 3
  ER lipid raft associated 2
  ER membrane protein complex subunit 2
  eukaryotic translation initiation factor 2 alpha kinase 3
  Fas associated factor family member 2
  F-box protein 6
  glucosidase II alpha subunit
  H4 clustered histone 1
  heat shock protein 90 beta family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  hydroxysteroid 17-beta dehydrogenase 12
  importin 9
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inner membrane mitochondrial protein
  integrin alpha FG-GAP repeat containing 1
  integrin beta 1 (fibronectin receptor beta)
  IQ motif containing B1
  kinesin family member 20B
  Kruppel like factor 16
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat kinase 2
  LIM domain and actin binding 1
  lysine demethylase 4B
  lysozyme like 2
  matrix Gla protein
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 23
  mitogen-activated protein kinase 13
  myosin light chain 12A
  NADH:ubiquinone oxidoreductase core subunit S7
  nipsnap homolog 1
  obscurin like cytoskeletal adaptor 1
  OS9 endoplasmic reticulum lectin
  peroxiredoxin 4
  phosphorylated adaptor for RNA export
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  potassium voltage-gated channel subfamily Q member 4
  prohibitin 2
  protein phosphatase methylesterase 1
  PTEN induced kinase 1
  RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
  RAB5 interacting factor
  RAB7A, member RAS oncogene family
  receptor for activated C kinase 1
  RecQ like helicase 4
  ribonucleic acid export 1
  ring finger and WD repeat domain 3
  ring finger protein 144A
  ring finger protein 181
  ring finger protein 185
  sel-1 suppressor of lin-12-like (C. elegans)
  serine and arginine rich splicing factor 9
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  shootin 1
  signal regulatory protein alpha
  sirtuin 3
  small glutamine rich tetratricopeptide repeat containing beta
  SMG1 nonsense mediated mRNA decay associated PI3K related kinase
  SNW domain containing 1
  solute carrier family 33 member 1
  succinate-CoA ligase GDP-forming subunit beta
  SUMO specific peptidase 3
  tectonic family member 1
  tectonic family member 2
  tectonic family member 3
  testis expressed 101
  thioredoxin domain containing 11
  TNFAIP3 interacting protein 2
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 5
  tripartite motif containing 68
  TSR1 ribosome maturation factor
  tubulin, alpha 3A
  U2 small nuclear RNA auxiliary factor 2
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquinol-cytochrome c reductase core protein 1
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin like modifier activating enzyme 5
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 25
  UDP-glucose glycoprotein glucosyltransferase 1
  USO1 vesicle transport factor
  valosin containing protein
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  von Willebrand factor
  WD repeat domain 76
  X-ray repair cross complementing 3
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 8 opposite strand
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.