CDK7, cyclin dependent kinase 7

CDK7, cyclin dependent kinase 7

• The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cyclin-dependent kinase 7, 39 KDa protein kinase, CDK-activating kinase 1, TFIIH basal transcription factor complex kinase subunit, cell division protein kinase 7, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), homolog of Xenopus MO15 Cdk-activating kinase, kinase subunit of CAK, serine/threonine kinase stk1, serine/threonine protein kinase 1, serine/threonine protein kinase MO15, CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15,)
• NCBI Gene ID: 1022
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D6R9G1
  UNIPROT ID#>>A0A0S2Z3F9
  UNIPROT ID#>>D6RFL0
  UNIPROT ID#>>P50613
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cyclin dependent kinase 7 interacts with:

• acyl-CoA dehydrogenase family member 11
  calcium binding and coiled-coil domain 2
  CCHC-type zinc finger nucleic acid binding protein
  cell cycle and apoptosis regulator 2
  cell division cycle 37, HSP90 cochaperone
  chaperonin containing TCP1 subunit 2
  coilin
  CTD phosphatase subunit 1
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cut like homeobox 1
  cyclin B2
  cyclin dependent kinase 20
  cyclin dependent kinase 7
  cyclin dependent kinase 9
  cyclin dependent kinase inhibitor 1B
  cyclin dependent kinase inhibitor 1C
  cyclin L1
  cyclin L2
  DEAD-box helicase 10
  DEAD-box helicase 56
  DEAH-box helicase 38
  DExD-box helicase 52
  DNA primase subunit 1
  E2F transcription factor 1
  elongation factor for RNA polymerase II
  elongin A
  enoyl-CoA hydratase 1
  ERCC excision repair 2, TFIIH core complex helicase subunit
  ERCC excision repair 3, TFIIH core complex helicase subunit
  ERCC excision repair 5, endonuclease
  estrogen receptor 1
  euchromatic histone lysine methyltransferase 1
  eukaryotic translation elongation factor 1 alpha 2
  FKBP prolyl isomerase 5
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 2
  general transcription factor IIE subunit 1
  general transcription factor IIE subunit 2
  general transcription factor IIH subunit 1
  general transcription factor IIH subunit 2
  general transcription factor IIH subunit 3
  general transcription factor IIH subunit 4
  general transcription factor IIH subunit 5
  general transcription factor IIIC subunit 1
  general transcription factor IIIC subunit 3
  general transcription factor IIIC subunit 5
  GTF2H2 family member C, copy 2
  GTP binding protein 4
  H1.1 linker histone, cluster member
  HDGF like 2
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein U
  histone deacetylase 2
  hydroxysteroid 17-beta dehydrogenase 4
  LAS1 like ribosome biogenesis factor
  LIM and SH3 protein 1
  Ly1 antibody reactive
  major histocompatibility complex, class II, DQ alpha 1
  marker of proliferation Ki-67
  MAX dimerization protein MGA
  mediator complex subunit 17
  mediator complex subunit 21
  mediator complex subunit 31
  metastasis associated 1
  metastasis associated 1 family member 3
  minichromosome maintenance complex component 7
  mitochondrial ribosomal protein S12
  MNAT1 component of CDK activating kinase
  M-phase specific PLK1 interacting protein
  MYC associated zinc finger protein
  myelin basic protein
  N-acetyltransferase 10
  NIMA related kinase 6
  nucleoporin 205
  pescadillo ribosomal biogenesis factor 1
  phosphatidylinositol 4-kinase beta
  PNN interacting serine and arginine rich protein
  polycomb group ring finger 6
  protein kinase C iota
  PWP1 homolog, endonuclein
  replication protein A1
  replication protein A2
  replication protein A3
  replication timing regulatory factor 1
  retinoic acid receptor alpha
  ribosomal protein L39
  ribosomal RNA processing 1B
  RNA binding motif protein 28
  RNA polymerase I subunit A
  RNA polymerase I subunit B
  RNA polymerase II subunit A
  RNA polymerase II subunit B
  RuvB like AAA ATPase 2
  SEC16 homolog A, endoplasmic reticulum export factor
  SMAD family member 1
  SPT5 homolog, DSIF elongation factor subunit
  SRSF protein kinase 1
  SRSF protein kinase 2
  surfeit 6
  SURP and G-patch domain containing 2
  TATA-box binding protein associated factor 1
  TATA-box binding protein associated factor 2
  TATA-box binding protein associated factor 4
  TATA-box binding protein associated factor 5
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  TBC1 domain family member 32
  thyroid hormone receptor alpha
  transcription elongation factor A1
  translocated promoter region, nuclear basket protein
  tumor protein p53
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  UV stimulated scaffold protein A
  vitamin D receptor
  YTH N6-methyladenosine RNA binding protein 3
  ZFP30 zinc finger protein
  zinc finger BED-type containing 1
  zinc finger protein 281

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.