PRDX4, peroxiredoxin 4

PRDX4, peroxiredoxin 4

• The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AOE37-2, AOE372, HEL-S-97n, PRX-4, peroxiredoxin-4, antioxidant enzyme AOE372, epididymis secretory sperm binding protein Li 97n, peroxiredoxin IV, prx-IV, thioredoxin peroxidase (antioxidant enzyme), thioredoxin peroxidase AO372, thioredoxin-dependent peroxide reductase A0372, thioredoxin-dependent peroxiredoxin 4,)
• NCBI Gene ID: 10549
• Species: Homo sapiens (Human)
• UNIPROT ID#>>V9HW63
  UNIPROT ID#>>Q13162
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peroxiredoxin 4 interacts with:

• AAR2 splicing factor
  ALG12 alpha-1,6-mannosyltransferase
  anterior gradient 2, protein disulphide isomerase family member
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  calreticulin 3
  cell division cycle associated 5
  complement factor H related 3
  dual specificity phosphatase 13
  dual specificity phosphatase 23
  egl-9 family hypoxia inducible factor 3
  glycolipid transfer protein domain containing 2
  HEXIM P-TEFb complex subunit 1
  kinase suppressor of ras 1
  leucine rich repeat kinase 2
  microtubule associated protein 1 light chain 3 alpha
  neutrophil cytosolic factor 1
  ninein
  peroxiredoxin 3
  peroxiredoxin 4
  phosphohistidine phosphatase 1
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  pyrroline-5-carboxylate reductase 2
  ring finger and CCCH-type domains 1
  ring finger and CHY zinc finger domain containing 1
  sirtuin 7
  small ubiquitin like modifier 4
  tectonic family member 1
  TNFAIP3 interacting protein 2
  tubulin, alpha 3A
  vir like m6A methyltransferase associated
  zinc finger protein 593
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.