HINT1, histidine triad nucleotide binding protein 1

HINT1, histidine triad nucleotide binding protein 1

• This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]

• Gene Synonyms (histidine triad nucleotide-binding protein 1, adenosine 5'-monophosphoramidase, epididymis secretory sperm binding protein, protein kinase C inhibitor 1, protein kinase C-interacting protein 1, HINT, NMAN, PKCI-1, PRKCNH1,)
• NCBI Gene ID: 3094
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49773
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

histidine triad nucleotide binding protein 1 interacts with:

• 3-oxoacid CoA-transferase 1
  acyl-CoA thioesterase 1
  aldo-keto reductase family 1 member B10
  aldo-keto reductase family 1 member B15
  beta-transducin repeat containing E3 ubiquitin protein ligase
  cell division cycle 16
  chloride intracellular channel 4
  chromosome 1 open reading frame 198
  chromosome 1 open reading frame 53
  cleavage and polyadenylation specific factor 7
  DDB1 and CUL4 associated factor 15
  DEAH-box helicase 36
  dimethylarginine dimethylaminohydrolase 2
  FKBP prolyl isomerase 7
  glutamine amidotransferase like class 1 domain containing 3A
  glutaredoxin 5
  glutathione S-transferase omega 2
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family E (Hsp10) member 1
  histidine triad nucleotide binding protein 1
  histone deacetylase 7
  histone deacetylase 9
  inorganic pyrophosphatase 2
  jumonji domain containing 8
  lactamase beta 2
  lymphoid enhancer binding factor 1
  LYR motif containing 2
  lysine acetyltransferase 5
  lysophospholipase like 1
  macrophage migration inhibitory factor
  melanocyte inducing transcription factor
  mercaptopyruvate sulfurtransferase
  methylthioadenosine phosphorylase
  myotrophin
  myristoylated alanine rich protein kinase C substrate
  neudesin neurotrophic factor
  nitric oxide synthase 2
  NME/NM23 nucleoside diphosphate kinase 2
  NME1-NME2 readthrough
  nuclear transport factor 2
  OFD1 centriole and centriolar satellite protein
  Parkinsonism associated deglycase
  PEDS1-UBE2V1 readthrough
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase B
  peptidyl-tRNA hydrolase domain containing 1
  peripheral myelin protein 2
  peroxiredoxin 2
  peroxiredoxin 5
  peroxiredoxin 6
  phosphoethanolamine/phosphocholine phosphatase 1
  prefoldin subunit 2
  prosaposin
  prostaglandin reductase 1
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RAB11 family interacting protein 5
  regucalcin
  ribonucleic acid export 1
  ring finger protein 4
  ring-box 1
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  sepiapterin reductase
  SH3 domain binding glutamate rich protein like
  SIN3 transcription regulator family member A
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  sodium channel and clathrin linker 1
  sorcin
  sorting nexin 24
  Sp1 transcription factor
  STIL centriolar assembly protein
  stress induced phosphoprotein 1
  superoxide dismutase 1
  teneurin transmembrane protein 1
  thioredoxin
  thioredoxin 2
  thioredoxin domain containing 12
  TNFAIP3 interacting protein 2
  TP53 induced glycolysis regulatory phosphatase
  transgelin
  transgelin 2
  transgelin 3
  transketolase
  tripartite motif containing 25
  tripartite motif containing 29
  tubulin folding cofactor A
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 V1
  ubiquitin C-terminal hydrolase L3
  ubiquitin-fold modifier conjugating enzyme 1
  unk zinc finger
  valosin containing protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.