PPIB, peptidylprolyl isomerase B

PPIB, peptidylprolyl isomerase B

• The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

• Gene Synonyms (peptidyl-prolyl cis-trans isomerase B, PPIase B, S-cyclophilin, cyclophilin-like protein, epididymis secretory protein Li 39, peptidylprolyl isomerase B (cyclophilin B), rotamase B, B, CYP-S1, CYPB, HEL-S-39, OI9, SCYLP,)
• NCBI Gene ID: 5479
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P23284
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peptidylprolyl isomerase B interacts with:

• AAR2 splicing factor
  anterior gradient 2, protein disulphide isomerase family member
  BTG3 associated nuclear protein
  calreticulin 3
  CDGSH iron sulfur domain 1
  cullin 7
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  eukaryotic translation initiation factor 5A like 1
  eukaryotic translation initiation factor 5A2
  expressed sequence AI837181
  F-box protein 6
  H3.4 histone
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HEXIM P-TEFb complex subunit 1
  inositol-3-phosphate synthase 1
  junction plakoglobin
  kinase suppressor of ras 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  magnesium transporter 1
  methylphosphate capping enzyme
  methyltransferase like 14
  MINDY lysine 48 deubiquitinase 4
  mitochondrial ribosomal protein L53
  mitochondrial ribosome recycling factor
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  OS9 endoplasmic reticulum lectin
  patched 1
  peroxisomal biogenesis factor 19
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pre-mRNA processing factor 8
  prolactin
  proline rich coiled-coil 1
  proline rich protein HaeIII subfamily 1
  proteasome 20S subunit alpha 4
  protein phosphatase 5 catalytic subunit
  protein tyrosine phosphatase receptor type N
  protein tyrosine phosphatase receptor type O
  PTEN induced kinase 1
  Ran GTPase activating protein 1
  ribonucleotide reductase catalytic subunit M1
  ribophorin I
  ring finger and CCCH-type domains 1
  RNA binding motif single stranded interacting protein 1
  signal transducer and activator of transcription 5A
  small glutamine rich tetratricopeptide repeat containing alpha
  small glutamine rich tetratricopeptide repeat containing beta
  succinate dehydrogenase complex flavoprotein subunit A
  SURP and G-patch domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  synthesis of cytochrome C oxidase 2
  tectonic family member 1
  tectonic family member 3
  thioredoxin domain containing 16
  thymopoietin
  TNFAIP3 interacting protein 2
  transgelin
  translocase of inner mitochondrial membrane 44
  transmembrane BAX inhibitor motif containing 4
  triadin
  tumor protein p53
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C-terminal hydrolase L3
  ubiquitin like 4A
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  vitamin K epoxide reductase complex subunit 1
  von Hippel-Lindau tumor suppressor
  WD repeat domain 48
  WD repeat domain 76
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger CCCH-type containing 11A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.